CARsgen Therapeutics Holdings Limited logo

CARsgen Therapeutics Holdings Limited

2171.HK

HKSEHealthcareBiotechnology

Latest quote

HK$13.29

−HK$0.24 · -1.77%

Aug 24, 11:58 AM HKT

2171.HK company overview

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Company profile

Company website

CARsgen Therapeutics Holdings Limited, a biopharmaceutical firm founded in Shanghai, China, in 2014, focuses on the discovery, development, and commercialization of advanced chimeric antigen receptor T (CAR-T) cell therapies. The company's efforts are directed toward treating various hematological malignancies and solid tumors across China and the United States. Its robust pipeline includes several key candidates: CT053, an autologous CAR-T product, is currently in a pivotal Phase II trial in China for relapsed/refractory multiple myeloma. Additionally, CT041, another autologous CAR-T, is undergoing Phase Ib/II clinical trials for advanced gastric/gastroesophageal junction and pancreatic cancers in China, and Phase Ib trials for comparable indications in the U.S. CARsgen is also advancing CT011, an autologous CAR-T candidate, through Phase I for patients with Glypican-3 positive advanced hepatocellular carcinoma, and CT032, an autologous CAR-T, in Phase I/II for B cell Non-Hodgkin's lymphoma in China. Furthermore, its pipeline features AB011, a humanized monoclonal antibody in Phase I for CLDN18.2 positive solid tumors in China, as well as CT017, an autologous Glypican-3-targeted CAR-T for hepatocellular carcinoma, and other promising therapies for solid tumors.

Industry
Biotechnology
Sector
Healthcare
Headquarters
CN
CEO
Zonghai Li
Listed since
Jun 18, 2021
Employees
355

Market position

Day range

Current HK$13.29

52-week range

Current HK$13.29

Open
HK$13.53
Previous close
HK$13.53
Volume
958K
0.17× average
Average volume
5.7M
Average daily volume
Market cap
7.57B HKD
Beta
0.26
Market reference 1
50-day average
HK$14.8312
-10.39% below average
200-day average
HK$16.5255
-19.58% below average

Financials

Financial snapshot

Latest / TTM

Valuation & yield

Enterprise value
6.3B CNY
P/E (TTM)
-70.98×
P/B (TTM)
5.75×
P/S (TTM)
47.82×
EV / EBITDA
-30.9×
Earnings yield
-1.33%
Free cash flow yield
-3.30%
Dividend yield
0.00%

Profitability & efficiency

Gross margin
59.69%
Operating margin
-119.90%
Net margin
-64.91%
Return on equity
-12.49%
Return on assets
-7.57%
Return on invested capital
-9.36%

Financial health

Debt / equity
0.07×
Current ratio
5.73×

Financial statements

Margin trends

Profitability as a percentage of reported revenue.

Gross marginOperating marginNet margin
Gross, operating, and net margin trends1948%-5444%-12836%-20228%Gross margin, FY2021: 100.00%Gross margin, FY2024: 37.41%Gross margin, FY2025: 63.62%Operating margin, FY2021: -2223.32%Operating margin, FY2024: -2049.95%Operating margin, FY2025: -82.93%Net margin, FY2021: -18379.98%Net margin, FY2024: -2024.43%Net margin, FY2025: -77.88%FY2021FY2022FY2023FY2024FY2025
Gross margin FY2021 100.00%. Gross margin FY2024 37.41%. Gross margin FY2025 63.62%. Operating margin FY2021 -2223.32%. Operating margin FY2024 -2049.95%. Operating margin FY2025 -82.93%. Net margin FY2021 -18379.98%. Net margin FY2024 -2024.43%. Net margin FY2025 -77.88%.

Income trends

Revenue

125.66M CNY+218.74%

Operating income

−104.21M CNY+87.11%

Net income

−97.86M CNY+87.74%
Income trends across reported periods612.67M CNY−1.34B CNY−3.28B CNY−5.23B CNYRevenue, FY2021: 25.81M CNYRevenue, FY2024: 39.43M CNYRevenue, FY2025: 125.66M CNYOperating income, FY2021: −573.91M CNYOperating income, FY2022: −881.3M CNYOperating income, FY2023: −767.65M CNYOperating income, FY2024: −808.19M CNYOperating income, FY2025: −104.21M CNYNet income, FY2021: −4.74B CNYNet income, FY2022: −892.25M CNYNet income, FY2023: −747.79M CNYNet income, FY2024: −798.13M CNYNet income, FY2025: −97.86M CNYFY2021FY2022FY2023FY2024FY2025
Revenue FY2021 25.81M CNY. Revenue FY2024 39.43M CNY. Revenue FY2025 125.66M CNY. Operating income FY2021 −573.91M CNY. Operating income FY2022 −881.3M CNY. Operating income FY2023 −767.65M CNY. Operating income FY2024 −808.19M CNY. Operating income FY2025 −104.21M CNY. Net income FY2021 −4.74B CNY. Net income FY2022 −892.25M CNY. Net income FY2023 −747.79M CNY. Net income FY2024 −798.13M CNY. Net income FY2025 −97.86M CNY.
Metric (CNY)FY2025FY2024FY2023FY2022FY2021
Revenue125.66M CNY39.43M CNY25.81M CNY
Cost of goods sold45.71M CNY24.68M CNY96.57M CNY94.81M CNY
Gross profit79.95M CNY14.75M CNY−96.57M CNY−94.81M CNY25.81M CNY
Research and development245.36M CNY466.19M CNY661.66M CNY680.3M CNY501.72M CNY
Selling, general, and administrative26.07M CNY52.02M CNY133.31M CNY136.61M CNY126.52M CNY
Operating expenses184.16M CNY822.94M CNY767.65M CNY881.3M CNY599.72M CNY
Interest income14.81M CNY41.92M CNY72.79M CNY27.57M CNY9.61M CNY
Interest expense6.9M CNY5.71M CNY4.66M CNY15.52M CNY10.87M CNY
Depreciation and amortization23.99M CNY65.14M CNY67.41M CNY56.92M CNY52.45M CNY
Operating income−104.21M CNY−808.19M CNY−767.65M CNY−881.3M CNY−573.91M CNY
Net income−97.86M CNY−798.13M CNY−747.79M CNY−892.25M CNY−4.74B CNY

Company facts updated Aug 24, 2026.

Earnings

EPS beat rate
50%
5 beats, 5 misses, 0 met estimates
Average EPS surprise
-16.85%
10 comparable reports
Latest EPS result
-0.15
Estimate -0.22 · Beat by 31.58%

EPS: actual versus estimate

Recent quarterly results

ActualEstimate
Quarterly EPS actual values compared with estimates-0.04-0.37-0.71-1.04Q3 '23MissQ1 '24BeatQ3 '24MissQ1 '25MissQ3 '25BeatQ1 '26BeatQ3 '26BeatQ1 '27Estimate
Q3 2023, reported Aug 22, 2023: actual -0.734, estimate -0.497, surprise -47.58%, Miss. Q1 2024, reported Mar 26, 2024: actual -0.682, estimate -0.968, surprise +29.55%, Beat. Q3 2024, reported Aug 28, 2024: actual -0.677, estimate -0.279, surprise -142.31%, Miss. Q1 2025, reported Mar 18, 2025: actual -0.862, estimate -0.426, surprise -102.50%, Miss. Q3 2025, reported Aug 14, 2025: actual -0.153, estimate -0.438, surprise +65.00%, Beat. Q1 2026, reported Mar 6, 2026: actual -0.045, estimate -0.156, surprise +71.42%, Beat. Q3 2026, reported Aug 18, 2026: actual -0.15, estimate -0.219, surprise +31.58%, Beat. Q1 2027, reported Mar 23, 2027: actual —, estimate -0.175, surprise —, Comparison unavailable.

Revenue: actual versus estimate

Recent quarterly results

ActualEstimate
Quarterly Revenue actual values compared with estimates284.14M191.36M98.57M5.79MQ3 '23EstimateQ1 '24EstimateQ3 '24MissQ1 '25MissQ3 '25BeatQ1 '26BeatQ3 '26MissQ1 '27Estimate
Q3 2023, reported Aug 22, 2023: actual —, estimate 216.13M HKD, surprise —, Comparison unavailable. Q1 2024, reported Mar 26, 2024: actual —, estimate 210.44M HKD, surprise —, Comparison unavailable. Q3 2024, reported Aug 28, 2024: actual 6.81M HKD, estimate 263.6M HKD, surprise -97.42%, Miss. Q1 2025, reported Mar 18, 2025: actual 35.21M HKD, estimate 72.72M HKD, surprise -51.58%, Miss. Q3 2025, reported Aug 14, 2025: actual 55.84M HKD, estimate 43M HKD, surprise +29.86%, Beat. Q1 2026, reported Mar 6, 2026: actual 83.13M HKD, estimate 66.39M HKD, surprise +25.22%, Beat. Q3 2026, reported Aug 18, 2026: actual 71.46M HKD, estimate 105.97M HKD, surprise -32.56%, Miss. Q1 2027, reported Mar 23, 2027: actual —, estimate 247.03M HKD, surprise —, Comparison unavailable.

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