Sirnaomics Ltd. logo

Sirnaomics Ltd.

2257.HK

HKSEHealthcareBiotechnology

Latest quote

HK$3.78

−HK$0.085 · -2.20%

Aug 24, 3:21 PM HKT

2257.HK company overview

Regular session · HKT · Market data may be delayed.

Company profile

Company website

Sirnaomics Ltd. is an RNA therapeutics biopharmaceutical company, founded in 2007 and headquartered in Gaithersburg, Maryland. The company is dedicated to identifying and developing innovative therapeutic compounds aimed at addressing significant medical needs across the United States and the People's Republic of China. Its leading pipeline assets include STP705, which is being investigated for conditions such as cutaneous squamous cell carcinoma in situ, basal cell carcinoma, various liver-related cancers (cholangiocarcinoma, hepatocellular carcinoma, liver metastases), as well as for keloid scar remodeling, hypertrophic scarring, and fat sculpting. Another prominent candidate, STP707, is designed to treat cholangiocarcinoma, hepatocellular carcinoma, liver metastases, metastatic cutaneous squamous cell carcinoma, non-small cell lung cancer, and both liver and lung fibrosis. Beyond these lead programs, Sirnaomics is advancing STP355 for a range of cancers; STP369 for head and neck/bladder cancers; STP779 for liver, lung, and pancreatic cancers; and STP902 for breast cancer. The company's portfolio also extends to infectious diseases with STP702 for influenza, STP908 for COVID-19, the RIM730 COVID-19 vaccine, and STP909 for HPV/cervical cancer. Furthermore, its developmental pipeline encompasses STP122G for thrombotic disorders, STP125G for hypertriglyceridemia, STP144G for complement-mediated ailments, STP133G for cardiometabolic conditions, and STP155G for hepatitis B virus.

Industry
Biotechnology
Sector
Healthcare
Headquarters
US
CEO
Hung Fai Poon
Listed since
Dec 30, 2021
Employees
37

Market position

Day range

Current HK$3.78

52-week range

Current HK$3.78

Open
HK$3.865
Previous close
HK$3.865
Volume
2.65K
0.03× average
Average volume
101.85K
Average daily volume
Market cap
411.64M HKD
Beta
-0.04
Market reference 1
50-day average
HK$4.3699
-13.50% below average
200-day average
HK$6.5162
-41.99% below average

Financials

Financial snapshot

Latest / TTM

Valuation & yield

Enterprise value
88.87M USD
P/E (TTM)
-3.23×
P/B (TTM)
-4.61×
P/S (TTM)
648.35×
EV / EBITDA
-6.57×
Earnings yield
-15.50%
Free cash flow yield
-9.94%
Dividend yield
0.00%

Profitability & efficiency

Gross margin
-999.61%
Operating margin
-18871.00%
Net margin
-17806.58%
Return on equity
145.51%
Return on assets
-70.01%
Return on invested capital
101.29%

Financial health

Debt / equity
-0.94×
Current ratio
0.4×
Altman Z-score
-45.14
Piotroski F-score
2 of 9

Financial statements

Margin trends

Profitability as a percentage of reported revenue.

Gross marginOperating marginNet margin
Gross, operating, and net margin trends2092%-5876%-13845%-21814%Gross margin, FY2022: 100.00%Gross margin, FY2023: 100.00%Gross margin, FY2024: 67.44%Operating margin, FY2022: -12925.82%Operating margin, FY2023: -19432.24%Operating margin, FY2024: -2067.72%Net margin, FY2022: -12524.68%Net margin, FY2023: -19821.41%Net margin, FY2024: -2889.93%FY2021FY2022FY2023FY2024FY2025
Gross margin FY2022 100.00%. Gross margin FY2023 100.00%. Gross margin FY2024 67.44%. Operating margin FY2022 -12925.82%. Operating margin FY2023 -19432.24%. Operating margin FY2024 -2067.72%. Net margin FY2022 -12524.68%. Net margin FY2023 -19821.41%. Net margin FY2024 -2889.93%.

Income trends

Revenue

1.78M USD+347.86%

Operating income

−15.37M USD+58.19%

Net income

−14.42M USD+71.93%
Income trends across reported periods167.57M USD−495.61M USD−1.16B USD−1.82B USDRevenue, FY2022: 705K USDRevenue, FY2023: 397K USDRevenue, FY2024: 1.78M USDOperating income, FY2021: −441.44M USDOperating income, FY2022: −91.13M USDOperating income, FY2023: −77.15M USDOperating income, FY2024: −36.76M USDOperating income, FY2025: −15.37M USDNet income, FY2021: −1.66B USDNet income, FY2022: −88.3M USDNet income, FY2023: −78.69M USDNet income, FY2024: −51.38M USDNet income, FY2025: −14.42M USDFY2021FY2022FY2023FY2024FY2025
Revenue FY2022 705K USD. Revenue FY2023 397K USD. Revenue FY2024 1.78M USD. Operating income FY2021 −441.44M USD. Operating income FY2022 −91.13M USD. Operating income FY2023 −77.15M USD. Operating income FY2024 −36.76M USD. Operating income FY2025 −15.37M USD. Net income FY2021 −1.66B USD. Net income FY2022 −88.3M USD. Net income FY2023 −78.69M USD. Net income FY2024 −51.38M USD. Net income FY2025 −14.42M USD.
Metric (USD)FY2025FY2024FY2023FY2022FY2021
Revenue1.78M USD397K USD705K USD
Cost of goods sold1.84M USD579K USD12.67M USD
Gross profit−1.84M USD1.2M USD397K USD705K USD−12.67M USD
Research and development8.99M USD20.8M USD54.38M USD67.64M USD306.02M USD
Selling, general, and administrative4.54M USD17.16M USD23.16M USD15.72M USD122.76M USD
Operating expenses13.53M USD37.96M USD77.54M USD91.83M USD428.77M USD
Interest income29.04K USD56K USD27K USD1.35M USD1.66M USD
Interest expense813.2K USD1.05M USD986K USD798K USD2.63M USD
Depreciation and amortization1.84M USD4.67M USD4.78M USD2.11M USD12.67M USD
Operating income−15.37M USD−36.76M USD−77.15M USD−91.13M USD−441.44M USD
Net income−14.42M USD−51.38M USD−78.69M USD−88.3M USD−1.66B USD

Company facts updated Aug 24, 2026.

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