CStone Pharmaceuticals logo

CStone Pharmaceuticals

2616.HK

HKSEHealthcareBiotechnology

Latest quote

HK$5.41

+HK$0.025 · +0.46%

Aug 24, 11:02 AM HKT

2616.HK company overview

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Company profile

Company website

CStone Pharmaceuticals is a biopharmaceutical company dedicated to the discovery, development, and commercialization of advanced immuno-oncology and precision medicines. Its mission is to address critical unmet medical needs for cancer patients, both within China and across the globe. The company's market-ready portfolio includes Sugemalimab, a monoclonal antibody targeting programmed death ligand 1 (PD-L1); GAVRETO, an RET inhibitor approved for advanced or metastatic RET-mutant medullary and RET fusion-positive thyroid cancers; and avapritinib, a KIT/PDGFRA inhibitor used to treat adults with unresectable or metastatic gastrointestinal stromal tumors featuring a PDGFRA exon 18 mutation. CStone also maintains a strong pipeline of investigational therapies, such as Nofazinlimab (a PD-1 antibody for hepatocellular carcinoma), Ivosidenib (an isocitrate dehydrogenase 1 (IDH1) inhibitor for adults with relapsed or refractory acute myeloid leukemia with an IDH1 mutation), and Fisogatinib (an FGFR4 inhibitor for hepatocellular carcinoma). Additional pipeline assets include CS1002, CS2006, CS3002, CS3005, CS2007, CS2008, and CS500, primarily for solid tumors, along with CS5001, intended for both solid and hematologic malignancies. Established in 2015, CStone Pharmaceuticals is headquartered in Shanghai, China.

Industry
Biotechnology
Sector
Healthcare
Headquarters
CN
CEO
Jianxin Yang
Listed since
Feb 26, 2019
Employees
136

Market position

Day range

Current HK$5.41

52-week range

Current HK$5.41

Open
HK$5.59
Previous close
HK$5.385
Volume
3.15M
0.32× average
Average volume
9.89M
Average daily volume
Market cap
8.65B HKD
Beta
0.25
Market reference 1
50-day average
HK$4.9421
+9.47% above average
200-day average
HK$6.3024
-14.16% below average

Financials

Financial snapshot

Latest / TTM

Valuation & yield

Enterprise value
6.17B CNY
P/E (TTM)
-22.08×
P/B (TTM)
10.99×
P/S (TTM)
30.28×
EV / EBITDA
-15.27×
Earnings yield
-6.65%
Free cash flow yield
-4.99%
Dividend yield
0.00%

Profitability & efficiency

Gross margin
39.88%
Operating margin
-120.09%
Net margin
-123.30%
Return on equity
-70.82%
Return on assets
-32.16%
Return on invested capital
-41.59%

Financial health

Debt / equity
0.57×
Current ratio
2.18×
Altman Z-score
-3.87
Piotroski F-score
2 of 9

Financial statements

Margin trends

Profitability as a percentage of reported revenue.

Gross marginOperating marginNet margin
Gross, operating, and net margin trends151%-190%-532%-873%Gross margin, FY2021: 56.17%Gross margin, FY2022: 57.83%Gross margin, FY2023: 65.60%Gross margin, FY2024: 58.98%Gross margin, FY2025: 19.01%Operating margin, FY2021: -750.64%Operating margin, FY2022: -189.49%Operating margin, FY2023: -130.55%Operating margin, FY2024: -22.52%Operating margin, FY2025: -160.48%Net margin, FY2021: -787.84%Net margin, FY2022: -187.53%Net margin, FY2023: -79.17%Net margin, FY2024: -22.40%Net margin, FY2025: -162.10%FY2021FY2022FY2023FY2024FY2025
Gross margin FY2021 56.17%. Gross margin FY2022 57.83%. Gross margin FY2023 65.60%. Gross margin FY2024 58.98%. Gross margin FY2025 19.01%. Operating margin FY2021 -750.64%. Operating margin FY2022 -189.49%. Operating margin FY2023 -130.55%. Operating margin FY2024 -22.52%. Operating margin FY2025 -160.48%. Net margin FY2021 -787.84%. Net margin FY2022 -187.53%. Net margin FY2023 -79.17%. Net margin FY2024 -22.40%. Net margin FY2025 -162.10%.

Income trends

Revenue

269.58M CNY-33.80%

Operating income

−432.62M CNY-371.82%

Net income

−437M CNY-379.13%
Income trends across reported periods721.51M CNY−239.08M CNY−1.2B CNY−2.16B CNYRevenue, FY2021: 243.72M CNYRevenue, FY2022: 481.36M CNYRevenue, FY2023: 463.84M CNYRevenue, FY2024: 407.21M CNYRevenue, FY2025: 269.58M CNYOperating income, FY2021: −1.83B CNYOperating income, FY2022: −912.15M CNYOperating income, FY2023: −605.57M CNYOperating income, FY2024: −91.69M CNYOperating income, FY2025: −432.62M CNYNet income, FY2021: −1.92B CNYNet income, FY2022: −902.68M CNYNet income, FY2023: −367.23M CNYNet income, FY2024: −91.21M CNYNet income, FY2025: −437M CNYFY2021FY2022FY2023FY2024FY2025
Revenue FY2021 243.72M CNY. Revenue FY2022 481.36M CNY. Revenue FY2023 463.84M CNY. Revenue FY2024 407.21M CNY. Revenue FY2025 269.58M CNY. Operating income FY2021 −1.83B CNY. Operating income FY2022 −912.15M CNY. Operating income FY2023 −605.57M CNY. Operating income FY2024 −91.69M CNY. Operating income FY2025 −432.62M CNY. Net income FY2021 −1.92B CNY. Net income FY2022 −902.68M CNY. Net income FY2023 −367.23M CNY. Net income FY2024 −91.21M CNY. Net income FY2025 −437M CNY.
Metric (CNY)FY2025FY2024FY2023FY2022FY2021
Revenue269.58M CNY407.21M CNY463.84M CNY481.36M CNY243.72M CNY
Cost of goods sold218.34M CNY167.05M CNY159.55M CNY202.99M CNY106.83M CNY
Gross profit51.25M CNY240.15M CNY304.3M CNY278.38M CNY136.89M CNY
Research and development311.5M CNY134.66M CNY527.8M CNY614.16M CNY1.3B CNY
Selling, general, and administrative172.36M CNY166.94M CNY248.07M CNY390.48M CNY472.99M CNY
Operating expenses483.87M CNY331.85M CNY909.86M CNY1.19B CNY1.97B CNY
Interest income10.12M CNY12.67M CNY24.89M CNY9.67M CNY9.8M CNY
Interest expense12.93M CNY15.17M CNY11.82M CNY8.48M CNY2.24M CNY
Depreciation and amortization11.98M CNY18.93M CNY58.19M CNY44.54M CNY22.66M CNY
Operating income−432.62M CNY−91.69M CNY−605.57M CNY−912.15M CNY−1.83B CNY
Net income−437M CNY−91.21M CNY−367.23M CNY−902.68M CNY−1.92B CNY

Company facts updated Aug 24, 2026.

Earnings

EPS beat rate
43%
3 beats, 4 misses, 0 met estimates
Average EPS surprise
-30.61%
7 comparable reports
Latest EPS result
-0.13
Estimate -0.06 · Miss by 140.03%

EPS: actual versus estimate

Recent quarterly results

ActualEstimate
Quarterly EPS actual values compared with estimates0.05-0.08-0.22-0.35Q3 '23BeatQ1 '24MissQ3 '24BeatQ4 '24No estimateQ1 '25MissQ3 '25MissQ1 '26MissQ3 '26Estimate
Q3 2023, reported Aug 16, 2023: actual -0.184, estimate -0.313, surprise +41.38%, Beat. Q1 2024, reported Mar 27, 2024: actual -0.143, estimate -0.11, surprise -30.01%, Miss. Q3 2024, reported Aug 23, 2024: actual 0.011, estimate -0.107, surprise +110.00%, Beat. Q4 2024, reported Dec 31, 2024: actual -0.089, estimate —, surprise —, Comparison unavailable. Q1 2025, reported Mar 25, 2025: actual -0.23, estimate -0.11, surprise -110.00%, Miss. Q3 2025, reported Aug 14, 2025: actual -0.23, estimate -0.11, surprise -110.00%, Miss. Q1 2026, reported Mar 26, 2026: actual -0.134, estimate -0.056, surprise -140.03%, Miss. Q3 2026, reported Aug 27, 2026: actual —, estimate -0.219, surprise —, Comparison unavailable.

Revenue: actual versus estimate

Recent quarterly results

ActualEstimate
Quarterly Revenue actual values compared with estimates439.35M308.25M177.16M46.06MQ3 '23MissQ1 '24MissQ3 '24MissQ4 '24No estimateQ1 '25MissQ3 '25MissQ1 '26BeatQ3 '26Estimate
Q3 2023, reported Aug 16, 2023: actual 282.56M HKD, estimate 384.5M HKD, surprise -26.51%, Miss. Q1 2024, reported Mar 27, 2024: actual 222.63M HKD, estimate 410.82M HKD, surprise -45.81%, Miss. Q3 2024, reported Aug 23, 2024: actual 273.08M HKD, estimate 331.93M HKD, surprise -17.73%, Miss. Q4 2024, reported Dec 31, 2024: actual 162.8M HKD, estimate —, surprise —, Comparison unavailable. Q1 2025, reported Mar 25, 2025: actual 54.19M HKD, estimate 118.19M HKD, surprise -54.15%, Miss. Q3 2025, reported Aug 14, 2025: actual 54.19M HKD, estimate 118.19M HKD, surprise -54.15%, Miss. Q1 2026, reported Mar 26, 2026: actual 244.98M HKD, estimate 231.39M HKD, surprise +5.87%, Beat. Q3 2026, reported Aug 27, 2026: actual —, estimate 158.17M HKD, surprise —, Comparison unavailable.

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