Alto Neuroscience, Inc. logo

Alto Neuroscience, Inc.

ANRO

NYSEHealthcareBiotechnology

Previous close

$34.28

+$0.03 · +0.09%

Aug 21, 4:00 PM ET

ANRO company overview

Regular session · ET · Market data may be delayed.

GoAI snapshot

AI-powered factor overview

Jul 10, 2026

GoAI score

Hold

Wait — insufficient conviction to act

Valuation

40

Expensive

Momentum

79

Gaining

Sentiment

61

Bullish

Risk resilience

55

Elevated Risk

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Company profile

Company website

Alto Neuroscience, Inc. operates as a biopharmaceutical entity in the clinical stage, specializing in the creation of novel psychiatric medications. Its development pipeline includes ALTO-100, an investigational therapy targeting individuals affected by major depressive disorder (MDD) and post-traumatic stress disorder. Also in its portfolio is ALTO-300, a small molecule designed to function as both a melatonergic agonist and serotonergic antagonist, exhibiting antidepressant properties for MDD patients. For addressing the cognitive impairments linked with schizophrenia, Alto Neuroscience is advancing ALTO-101, an innovative small molecule phosphodiesterase 4 inhibitor. The company's therapeutic candidates further extend to ALTO-203, a pioneering small-molecule histamine H3 receptor inverse agonist intended for MDD patients experiencing heightened anhedonia, and ALTO-202, an orally available antagonist of the GluN2B subunit of the NMDA receptor, also under investigation for MDD. Beyond these individual drug candidates, the firm is engaged in developing novel drug combinations that demonstrate synergistic pharmacodynamic effects. Crucially, Alto Neuroscience leverages an advanced AI-enabled biomarker platform that synthesizes data concerning patients' brain activity and behavioral patterns. This platform's purpose is to accurately identify which individuals are most likely to respond positively to its cutting-edge product candidates. Alto Neuroscience, Inc., established in 2019, maintains its headquarters in Los Altos, California.

Industry
Biotechnology
Sector
Healthcare
Headquarters
US
CEO
Amit Etkin
Listed since
Feb 2, 2024
Employees
68

Market position

Day range

Current $34.28

52-week range

Current $34.28

Open
$34.44
Previous close
$34.25
Volume
238.71K
0.52× average
Average volume
459.2K
Average daily volume
Market cap
1.2B USD
Beta
1.09
Market reference 1
50-day average
$27.262
+25.74% above average
200-day average
$21.0723
+62.68% above average

Financials

Financial snapshot

Latest / TTM

Valuation & yield

P/E (TTM)
-13.82×
P/B (TTM)
6.69×
P/S (TTM)
Dividend yield
0.00%

Profitability & efficiency

Gross margin
0.00%
Operating margin
0.00%
Net margin
0.00%

Financial health

Debt / equity
0.03×
Altman Z-score
19.35
Piotroski F-score
2 of 9

Financial statements

Income trends

Operating income

−66.36M USD+3.27%

Net income

−63.24M USD-2.94%
Income trends across reported periods−3.24M USD−27.01M USD−50.78M USD−74.55M USDOperating income, FY2021: −12.06M USDOperating income, FY2022: −29.19M USDOperating income, FY2023: −37.81M USDOperating income, FY2024: −68.61M USDOperating income, FY2025: −66.36M USDNet income, FY2021: −9.19M USDNet income, FY2022: −27.71M USDNet income, FY2023: −36.31M USDNet income, FY2024: −61.43M USDNet income, FY2025: −63.24M USDFY2021FY2022FY2023FY2024FY2025
Operating income FY2021 −12.06M USD. Operating income FY2022 −29.19M USD. Operating income FY2023 −37.81M USD. Operating income FY2024 −68.61M USD. Operating income FY2025 −66.36M USD. Net income FY2021 −9.19M USD. Net income FY2022 −27.71M USD. Net income FY2023 −36.31M USD. Net income FY2024 −61.43M USD. Net income FY2025 −63.24M USD.
Metric (USD)FY2025FY2024FY2023FY2022FY2021
Revenue210K USD
Cost of goods sold661K USD502K USD342K USD145K USD
Gross profit−661K USD−502K USD−342K USD65K USD
Research and development45.62M USD47M USD30.29M USD23.69M USD8.37M USD
Selling, general, and administrative20.75M USD21.61M USD7.52M USD5.16M USD3.75M USD
Operating expenses65.7M USD68.11M USD37.81M USD28.85M USD12.12M USD
Interest income6.6M USD8.85M USD2.35M USD114K USD2K USD
Interest expense2.47M USD−1.38M USD1.37M USD
Depreciation and amortization661K USD502K USD373K USD342K USD145K USD
Operating income−66.36M USD−68.61M USD−37.81M USD−29.19M USD−12.06M USD
Net income−63.24M USD−61.43M USD−36.31M USD−27.71M USD−9.19M USD

Company facts updated Aug 24, 2026.

Earnings

EPS beat rate
64%
7 beats, 4 misses, 0 met estimates
Average EPS surprise
-35.28%
11 comparable reports
Latest EPS result
-0.65
Estimate -0.73 · Beat by 11.51%

EPS: actual versus estimate

Recent quarterly results

ActualEstimate
Quarterly EPS actual values compared with estimates-0.41-0.55-0.7-0.84Q1 '25BeatQ2 '25BeatQ3 '25MissQ4 '25BeatQ1 '26BeatQ2 '26MissQ3 '26BeatQ4 '26Estimate
Q1 2025, reported Mar 20, 2025: actual -0.56, estimate -0.65, surprise +13.85%, Beat. Q2 2025, reported May 14, 2025: actual -0.53, estimate -0.59, surprise +10.17%, Beat. Q3 2025, reported Aug 13, 2025: actual -0.65, estimate -0.57, surprise -14.04%, Miss. Q4 2025, reported Nov 12, 2025: actual -0.52, estimate -0.66, surprise +21.21%, Beat. Q1 2026, reported Mar 16, 2026: actual -0.45, estimate -0.56, surprise +19.64%, Beat. Q2 2026, reported May 13, 2026: actual -0.8, estimate -0.56, surprise -42.86%, Miss. Q3 2026, reported Aug 12, 2026: actual -0.65, estimate -0.735, surprise +11.51%, Beat. Q4 2026, reported Nov 11, 2026: actual —, estimate -0.673, surprise —, Comparison unavailable.

Analyst ratings

Third-party consensus; not a GoAI recommendation.

Analyst price target

Average target

$37.40

9.10% upside
Past 12 months12-month forecast

Price history unavailable

High $55.00Average $37.40Low $24.00

Recent analyst actions

9 institutions
HC Wainwright& Co.maintainBuy
Jones TradingmaintainBuy
JefferiesmaintainBuy

ANRO peers

ETFs holding ANRO

Funds reporting this stock among their holdings, ordered by reported position size.

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