Axsome Therapeutics, Inc. logo

Axsome Therapeutics, Inc.

AXSM

NASDAQHealthcareBiotechnology

Previous close

$207.77

−$0.26 · -0.12%

Aug 21, 4:00 PM ET

AXSM company overview

Regular session · ET · Market data may be delayed.

GoAI snapshot

AI-powered factor overview

Jul 10, 2026

GoAI score

Buy

Favorable setup — positive multi-factor alignment

Valuation

66

Undervalued

Momentum

59

Neutral

Sentiment

64

Bullish

Risk resilience

73

Moderate Risk

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Company profile

Company website

Axsome Therapeutics, Inc. is a biopharmaceutical company dedicated to discovering and advancing innovative treatments for a range of central nervous system (CNS) disorders within the United States. Its robust product pipeline features several promising candidates, including: AXS-05, an investigational therapy currently being developed for major depressive disorder and treatment-resistant depression. This compound is also in Phase III clinical evaluation for Alzheimer's disease agitation and has successfully finished Phase II trials investigating its use for smoking cessation. AXS-07, a novel, orally administered, rapidly-acting investigational medicine that employs multiple mechanisms of action. It has concluded two Phase III studies for the acute treatment of migraine attacks. AXS-12, a selective and potent norepinephrine reuptake inhibitor, which is presently undergoing a Phase III trial for narcolepsy. AXS-14, an oral investigational drug, advancing through Phase III trials for the management of fibromyalgia. Axsome Therapeutics also engages in a research collaboration with Duke University to further assess AXS-05's potential in smoking cessation. The company, established in 2012, has its main offices in New York, New York.

Industry
Biotechnology
Sector
Healthcare
Headquarters
US
CEO
Herriot Tabuteau
Listed since
Nov 19, 2015
Employees
1,346

Market position

Day range

Current $207.77

52-week range

Current $207.77

Open
$209.33
Previous close
$208.03
Volume
734.95K
0.86× average
Average volume
858.64K
Average daily volume
Market cap
10.69B USD
Beta
0.6
Market reference 1
50-day average
$232.4
-10.60% below average
200-day average
$191.43
+8.54% above average

Financials

Financial snapshot

Latest / TTM

Valuation & yield

Enterprise value
9B USD
P/E (TTM)
-55.41×
P/B (TTM)
128.45×
P/S (TTM)
13.77×
EV / EBITDA
-53.57×
Earnings yield
-2.02%
Free cash flow yield
-1.03%
Dividend yield
0.00%

Profitability & efficiency

Gross margin
93.24%
Operating margin
-24.28%
Net margin
-24.68%
Return on equity
-207.46%
Return on assets
-26.55%
Return on invested capital
-43.95%

Financial health

Debt / equity
2.63×
Current ratio
1.55×

Financial statements

Margin trends

Profitability as a percentage of reported revenue.

Gross marginOperating marginNet margin
Gross, operating, and net margin trends139%-47%-234%-421%Gross margin, FY2022: 89.61%Gross margin, FY2023: 90.37%Gross margin, FY2024: 91.37%Gross margin, FY2025: 92.56%Operating margin, FY2022: -359.33%Operating margin, FY2023: -85.67%Operating margin, FY2024: -72.74%Operating margin, FY2025: -26.51%Net margin, FY2022: -373.99%Net margin, FY2023: -88.41%Net margin, FY2024: -74.47%Net margin, FY2025: -28.69%FY2021FY2022FY2023FY2024FY2025
Gross margin FY2022 89.61%. Gross margin FY2023 90.37%. Gross margin FY2024 91.37%. Gross margin FY2025 92.56%. Operating margin FY2022 -359.33%. Operating margin FY2023 -85.67%. Operating margin FY2024 -72.74%. Operating margin FY2025 -26.51%. Net margin FY2022 -373.99%. Net margin FY2023 -88.41%. Net margin FY2024 -74.47%. Net margin FY2025 -28.69%.

Income trends

Revenue

638.5M USD+65.55%

Operating income

−169.24M USD+39.68%

Net income

−183.17M USD+36.22%
Income trends across reported periods731.07M USD360.78M USD−9.5M USD−379.79M USDRevenue, FY2022: 50.04M USDRevenue, FY2023: 270.6M USDRevenue, FY2024: 385.69M USDRevenue, FY2025: 638.5M USDOperating income, FY2021: −124.71M USDOperating income, FY2022: −179.8M USDOperating income, FY2023: −231.83M USDOperating income, FY2024: −280.56M USDOperating income, FY2025: −169.24M USDNet income, FY2021: −130.4M USDNet income, FY2022: −187.13M USDNet income, FY2023: −239.24M USDNet income, FY2024: −287.22M USDNet income, FY2025: −183.17M USDFY2021FY2022FY2023FY2024FY2025
Revenue FY2022 50.04M USD. Revenue FY2023 270.6M USD. Revenue FY2024 385.69M USD. Revenue FY2025 638.5M USD. Operating income FY2021 −124.71M USD. Operating income FY2022 −179.8M USD. Operating income FY2023 −231.83M USD. Operating income FY2024 −280.56M USD. Operating income FY2025 −169.24M USD. Net income FY2021 −130.4M USD. Net income FY2022 −187.13M USD. Net income FY2023 −239.24M USD. Net income FY2024 −287.22M USD. Net income FY2025 −183.17M USD.
Metric (USD)FY2025FY2024FY2023FY2022FY2021
Revenue638.5M USD385.69M USD270.6M USD50.04M USD
Cost of goods sold47.48M USD33.3M USD26.07M USD5.2M USD
Gross profit591.02M USD352.39M USD244.54M USD44.84M USD
Research and development183.28M USD187.08M USD97.94M USD57.95M USD58.06M USD
Selling, general, and administrative570.6M USD411.36M USD323.12M USD159.25M USD66.65M USD
Operating expenses760.25M USD632.95M USD476.36M USD224.64M USD124.71M USD
Interest income9.37M USD
Interest expense6.56M USD6.57M USD6.45M USD7.34M USD5.7M USD
Depreciation and amortization9.06M USD7.96M USD6.83M USD4.4M USD76K USD
Operating income−169.24M USD−280.56M USD−231.83M USD−179.8M USD−124.71M USD
Net income−183.17M USD−287.22M USD−239.24M USD−187.13M USD−130.4M USD

Company facts updated Aug 24, 2026.

Analyst ratings

Third-party consensus; not a GoAI recommendation.

Analyst price target

Average target

$282.53

35.98% upside
Past 12 months12-month forecastHigh $380Average $282.53Low $246

Rating distribution

26 ratings
Strong buy00%
Buy2596%
Hold14%
Sell00%
Strong sell00%

AXSM peers

ETFs holding AXSM

Funds reporting this stock among their holdings, ordered by reported position size.

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