BioCryst Pharmaceuticals, Inc. logo

BioCryst Pharmaceuticals, Inc.

BCRX

NASDAQHealthcareBiotechnology

Latest quote

$9.68

+$0.13 · +1.36%

Aug 24, 4:00 PM ET

After-hours

$9.68

$0.00 · 0.00%

Aug 24, 4:10 PM ET

BCRX company overview

Regular session · ET · Market data may be delayed.

GoAI snapshot

AI-powered factor overview

Jul 10, 2026

GoAI score

Buy

Favorable setup — positive multi-factor alignment

Valuation

82

Deep Value

Momentum

67

Gaining

Sentiment

75

Bullish

Risk resilience

64

Moderate Risk

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Company profile

Company website

BioCryst Pharmaceuticals, Inc. is a biotechnology company focused on discovering and developing novel, orally administered, small-molecule therapeutics. The company currently markets two key products: Peramivir injection: An intravenous neuraminidase inhibitor, sold under the brand names RAPIVAB, RAPIACTA, and PERAMIFLU, used for the treatment of acute uncomplicated influenza. ORLADEYO: An oral serine protease inhibitor designed to manage hereditary angioedema. BioCryst's development pipeline includes several promising candidates: BCX9930: An oral factor D inhibitor in Phase II clinical trials for complement-mediated diseases. BCX9250: An oral activin receptor-like kinase-2 inhibitor undergoing Phase I clinical evaluation for fibrodysplasia ossificans progressiva. Galidesivir: An RNA dependent-RNA polymerase inhibitor, also in Phase I, aimed at treating a range of RNA viruses, including Marburg, Yellow Fever, Ebola, and Zika. The company engages in strategic collaborations and in-license agreements with numerous partners. These include pharmaceutical entities like Torii Pharmaceutical Co., Ltd., Seqirus UK Limited, Shionogi & Co., Ltd., Green Cross Corporation, and Mundipharma International Holdings Limited. Their alliances also extend to governmental and academic organizations such as the National Institute of Allergy and Infectious Diseases, the Biomedical Advanced Research and Development Authority, the U.S. Department of Health and Human Services, The University of Alabama at Birmingham, Albert Einstein College of Medicine of Yeshiva University, and Industrial Research, Ltd. Established in 1986, BioCryst Pharmaceuticals, Inc. is headquartered in Durham, North Carolina.

Industry
Biotechnology
Sector
Healthcare
Headquarters
US
CEO
Charles K. Gayer
Listed since
Mar 4, 1994
Employees
435

Market position

Day range

Current $9.68

52-week range

Current $9.68

Open
$9.49
Previous close
$9.55
Volume
1.94M
0.43× average
Average volume
4.5M
Average daily volume
Market cap
2.46B USD
Beta
0.55
Market reference 1
50-day average
$9.60
+0.83% above average
200-day average
$8.4311
+14.81% above average

Financials

Financial snapshot

Latest / TTM

Valuation & yield

Enterprise value
1.99B USD
P/E (TTM)
-6.73×
P/B (TTM)
-5.42×
P/S (TTM)
2.62×
EV / EBITDA
5.71×
Earnings yield
16.12%
Free cash flow yield
20.00%
Dividend yield
0.00%

Profitability & efficiency

Gross margin
23.52%
Operating margin
-33.29%
Net margin
-40.90%
Return on equity
-221.45%
Return on assets
51.32%
Return on invested capital
105.24%

Financial health

Debt / equity
-0.9×
Current ratio
2.06×
Altman Z-score
-3.5
Piotroski F-score
5 of 9

Financial statements

Margin trends

Profitability as a percentage of reported revenue.

Gross marginOperating marginNet margin
Gross, operating, and net margin trends120%34%-52%-139%Gross margin, FY2021: 95.38%Gross margin, FY2022: 97.57%Gross margin, FY2023: 98.59%Gross margin, FY2024: 97.23%Gross margin, FY2025: 97.82%Operating margin, FY2021: -113.08%Operating margin, FY2022: -54.81%Operating margin, FY2023: -31.29%Operating margin, FY2024: -0.56%Operating margin, FY2025: 38.98%Net margin, FY2021: -117.11%Net margin, FY2022: -91.24%Net margin, FY2023: -68.36%Net margin, FY2024: -19.72%Net margin, FY2025: 30.16%FY2021FY2022FY2023FY2024FY2025
Gross margin FY2021 95.38%. Gross margin FY2022 97.57%. Gross margin FY2023 98.59%. Gross margin FY2024 97.23%. Gross margin FY2025 97.82%. Operating margin FY2021 -113.08%. Operating margin FY2022 -54.81%. Operating margin FY2023 -31.29%. Operating margin FY2024 -0.56%. Operating margin FY2025 38.98%. Net margin FY2021 -117.11%. Net margin FY2022 -91.24%. Net margin FY2023 -68.36%. Net margin FY2024 -19.72%. Net margin FY2025 30.16%.

Income trends

Revenue

874.84M USD+94.10%

Operating income

340.99M USD+343.53M USD

Net income

263.86M USD+352.74M USD
Income trends across reported periods987.03M USD538.25M USD89.47M USD−359.31M USDRevenue, FY2021: 157.17M USDRevenue, FY2022: 270.83M USDRevenue, FY2023: 331.41M USDRevenue, FY2024: 450.71M USDRevenue, FY2025: 874.84M USDOperating income, FY2021: −177.72M USDOperating income, FY2022: −148.44M USDOperating income, FY2023: −103.71M USDOperating income, FY2024: −2.54M USDOperating income, FY2025: 340.99M USDNet income, FY2021: −184.06M USDNet income, FY2022: −247.12M USDNet income, FY2023: −226.54M USDNet income, FY2024: −88.88M USDNet income, FY2025: 263.86M USDFY2021FY2022FY2023FY2024FY2025
Revenue FY2021 157.17M USD. Revenue FY2022 270.83M USD. Revenue FY2023 331.41M USD. Revenue FY2024 450.71M USD. Revenue FY2025 874.84M USD. Operating income FY2021 −177.72M USD. Operating income FY2022 −148.44M USD. Operating income FY2023 −103.71M USD. Operating income FY2024 −2.54M USD. Operating income FY2025 340.99M USD. Net income FY2021 −184.06M USD. Net income FY2022 −247.12M USD. Net income FY2023 −226.54M USD. Net income FY2024 −88.88M USD. Net income FY2025 263.86M USD.
Metric (USD)FY2025FY2024FY2023FY2022FY2021
Revenue874.84M USD450.71M USD331.41M USD270.83M USD157.17M USD
Cost of goods sold19.08M USD12.49M USD4.66M USD6.59M USD7.26M USD
Gross profit855.76M USD438.23M USD326.75M USD264.23M USD149.91M USD
Research and development166.13M USD174.64M USD216.57M USD253.3M USD208.81M USD
Selling, general, and administrative348.65M USD266.13M USD213.89M USD159.37M USD118.82M USD
Operating expenses514.77M USD440.77M USD430.46M USD412.67M USD327.63M USD
Interest income10.67M USD14.75M USD15.78M USD5.13M USD62K USD
Interest expense78.87M USD98.52M USD108.24M USD99.09M USD59.29M USD
Depreciation and amortization1.39M USD1.25M USD1.66M USD1.44M USD777K USD
Operating income340.99M USD−2.54M USD−103.71M USD−148.44M USD−177.72M USD
Net income263.86M USD−88.88M USD−226.54M USD−247.12M USD−184.06M USD

Company facts updated Aug 24, 2026.

Earnings

EPS beat rate
45%
5 beats, 5 misses, 1 met estimate
Average EPS surprise
-311.58%
11 comparable reports
Latest EPS result
0.3
Estimate 0.15 · Beat by 94.55%

EPS: actual versus estimate

Recent quarterly results

ActualEstimate
Quarterly EPS actual values compared with estimates1.45-0.14-1.72-3.31Q1 '25MissQ2 '25BeatQ3 '25MissQ4 '25MissQ1 '26BeatQ2 '26MissQ3 '26BeatQ4 '26Estimate
Q1 2025, reported Feb 24, 2025: actual -0.13, estimate -0.07, surprise -85.71%, Miss. Q2 2025, reported May 5, 2025: actual 0, estimate -0.07, surprise +100.21%, Beat. Q3 2025, reported Aug 4, 2025: actual 0.02, estimate 0.03, surprise -33.33%, Miss. Q4 2025, reported Nov 3, 2025: actual 0.06, estimate 0.07, surprise -14.29%, Miss. Q1 2026, reported Feb 26, 2026: actual 1.12, estimate 0.07, surprise +1500.00%, Beat. Q2 2026, reported May 6, 2026: actual -2.98, estimate 0.06, surprise -5066.67%, Miss. Q3 2026, reported Aug 5, 2026: actual 0.3, estimate 0.154, surprise +94.55%, Beat. Q4 2026, reported Nov 2, 2026: actual —, estimate 0.1, surprise —, Comparison unavailable.

Revenue: actual versus estimate

Recent quarterly results

ActualEstimate
Quarterly Revenue actual values compared with estimates428.95M321.85M214.74M107.64MQ1 '25BeatQ2 '25MissQ3 '25BeatQ4 '25BeatQ1 '26BeatQ2 '26BeatQ3 '26BeatQ4 '26Estimate
Q1 2025, reported Feb 24, 2025: actual 131.53M USD, estimate 126.64M USD, surprise +3.87%, Beat. Q2 2025, reported May 5, 2025: actual 145.53M USD, estimate 149.72M USD, surprise -2.80%, Miss. Q3 2025, reported Aug 4, 2025: actual 163.35M USD, estimate 149.82M USD, surprise +9.03%, Beat. Q4 2025, reported Nov 3, 2025: actual 159.4M USD, estimate 151.32M USD, surprise +5.34%, Beat. Q1 2026, reported Feb 26, 2026: actual 406.56M USD, estimate 151.32M USD, surprise +168.66%, Beat. Q2 2026, reported May 6, 2026: actual 156.41M USD, estimate 151.12M USD, surprise +3.50%, Beat. Q3 2026, reported Aug 5, 2026: actual 218.25M USD, estimate 183.28M USD, surprise +19.08%, Beat. Q4 2026, reported Nov 2, 2026: actual —, estimate 165.38M USD, surprise —, Comparison unavailable.

Analyst ratings

Third-party consensus; not a GoAI recommendation.

Analyst price target

Average target

$20.00

106.61% upside
Past 12 months12-month forecastHigh $29.00Average $20.00Low $14.00

Rating distribution

29 ratings
Strong buy00%
Buy2586%
Hold414%
Sell00%
Strong sell00%

Recent analyst actions

12 institutions

BCRX news

BCRX peers

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Funds reporting this stock among their holdings, ordered by reported position size.

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