Caribou Biosciences, Inc. logo

Caribou Biosciences, Inc.

CRBU

NASDAQHealthcareBiotechnology

Previous close

$1.66

+$0.05 · +3.11%

Aug 21, 4:00 PM ET

CRBU company overview

Regular session · ET · Market data may be delayed.

GoAI snapshot

AI-powered factor overview

Jul 10, 2026

GoAI score

Sell

Trim exposure — unfavorable risk-reward

Valuation

42

Fair Value

Momentum

57

Neutral

Sentiment

43

Mixed

Risk resilience

21

High Risk

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Company profile

Company website

Caribou Biosciences, Inc. operates as a clinical-stage biopharmaceutical firm dedicated to pioneering genome-edited allogeneic cell therapies. These cutting-edge treatments are engineered to address both hematologic malignancies (blood cancers) and solid tumors, serving patients across the United States and internationally. Among its primary therapeutic candidates are CB-010, an allogeneic anti-CD19 CAR-T cell therapy currently undergoing Phase 1 clinical trials for relapsed or refractory B cell non-Hodgkin lymphoma, and CB-011, an allogeneic anti-BCMA CAR-T cell therapy targeting relapsed or refractory multiple myeloma. Caribou Biosciences is additionally developing CB-012, an allogeneic anti-CD371 CAR-T cell therapy for relapsed or refractory acute myeloid leukemia, along with CB-020, an allogeneic CAR-NK cell therapy aimed at solid tumors. The company also maintains a collaborative agreement with AbbVie Manufacturing Management Unlimited Company for the joint advancement of CAR-T cell therapies. Founded in 2011, Caribou Biosciences' headquarters are located in Berkeley, California.

Industry
Biotechnology
Sector
Healthcare
Headquarters
US
CEO
Rachel E. Haurwitz
Listed since
Jul 23, 2021
Employees
97

Market position

Day range

Current $1.66

52-week range

Current $1.66

Open
$1.67
Previous close
$1.61
Volume
1.16M
0.65× average
Average volume
1.79M
Average daily volume
Market cap
164.64M USD
Beta
2.28
Market reference 1
50-day average
$1.665
-0.30% below average
200-day average
$1.8157
-8.58% below average

Financials

Financial snapshot

Latest / TTM

Valuation & yield

Enterprise value
163.36M USD
P/E (TTM)
-1.54×
P/B (TTM)
1.71×
P/S (TTM)
16.41×
EV / EBITDA
-1.13×
Earnings yield
-99.75%
Free cash flow yield
-75.66%
Dividend yield
0.00%

Profitability & efficiency

Gross margin
-129.70%
Operating margin
-1090.90%
Net margin
-1030.42%
Return on equity
-121.24%
Return on assets
-84.47%
Return on invested capital
-89.77%

Financial health

Debt / equity
0.27×
Current ratio
5.71×

Financial statements

Margin trends

Profitability as a percentage of reported revenue.

Gross marginOperating marginNet margin
Gross, operating, and net margin trends265%-437%-1140%-1843%Gross margin, FY2021: 89.75%Gross margin, FY2022: 73.71%Gross margin, FY2023: 89.78%Gross margin, FY2024: 60.71%Gross margin, FY2025: 67.34%Operating margin, FY2021: -697.84%Operating margin, FY2022: -768.17%Operating margin, FY2023: -336.63%Operating margin, FY2024: -1667.16%Operating margin, FY2025: -1220.49%Net margin, FY2021: -697.26%Net margin, FY2022: -717.79%Net margin, FY2023: -296.05%Net margin, FY2024: -1491.95%Net margin, FY2025: -1327.40%FY2021FY2022FY2023FY2024FY2025
Gross margin FY2021 89.75%. Gross margin FY2022 73.71%. Gross margin FY2023 89.78%. Gross margin FY2024 60.71%. Gross margin FY2025 67.34%. Operating margin FY2021 -697.84%. Operating margin FY2022 -768.17%. Operating margin FY2023 -336.63%. Operating margin FY2024 -1667.16%. Operating margin FY2025 -1220.49%. Net margin FY2021 -697.26%. Net margin FY2022 -717.79%. Net margin FY2023 -296.05%. Net margin FY2024 -1491.95%. Net margin FY2025 -1327.40%.

Income trends

Revenue

11.16M USD+11.66%

Operating income

−136.19M USD+18.26%

Net income

−148.13M USD+0.66%
Income trends across reported periods54.59M USD−25.85M USD−106.29M USD−186.73M USDRevenue, FY2021: 9.6M USDRevenue, FY2022: 13.85M USDRevenue, FY2023: 34.48M USDRevenue, FY2024: 9.99M USDRevenue, FY2025: 11.16M USDOperating income, FY2021: −66.98M USDOperating income, FY2022: −106.4M USDOperating income, FY2023: −116.06M USDOperating income, FY2024: −166.62M USDOperating income, FY2025: −136.19M USDNet income, FY2021: −66.92M USDNet income, FY2022: −99.42M USDNet income, FY2023: −102.07M USDNet income, FY2024: −149.11M USDNet income, FY2025: −148.13M USDFY2021FY2022FY2023FY2024FY2025
Revenue FY2021 9.6M USD. Revenue FY2022 13.85M USD. Revenue FY2023 34.48M USD. Revenue FY2024 9.99M USD. Revenue FY2025 11.16M USD. Operating income FY2021 −66.98M USD. Operating income FY2022 −106.4M USD. Operating income FY2023 −116.06M USD. Operating income FY2024 −166.62M USD. Operating income FY2025 −136.19M USD. Net income FY2021 −66.92M USD. Net income FY2022 −99.42M USD. Net income FY2023 −102.07M USD. Net income FY2024 −149.11M USD. Net income FY2025 −148.13M USD.
Metric (USD)FY2025FY2024FY2023FY2022FY2021
Revenue11.16M USD9.99M USD34.48M USD13.85M USD9.6M USD
Cost of goods sold3.65M USD3.93M USD3.53M USD3.64M USD984K USD
Gross profit7.51M USD6.07M USD30.95M USD10.21M USD8.61M USD
Research and development109.44M USD130.15M USD112.08M USD82.23M USD52.26M USD
Selling, general, and administrative37.91M USD46.46M USD38.46M USD38.02M USD23.34M USD
Operating expenses143.71M USD172.68M USD147.01M USD116.61M USD75.59M USD
Interest income8M USD10.7M USD4.6M USD148K USD
Interest expense8K USD
Depreciation and amortization3.65M USD3.93M USD3.53M USD3.64M USD984K USD
Operating income−136.19M USD−166.62M USD−116.06M USD−106.4M USD−66.98M USD
Net income−148.13M USD−149.11M USD−102.07M USD−99.42M USD−66.92M USD

Company facts updated Aug 24, 2026.

Earnings

EPS beat rate
73%
8 beats, 2 misses, 1 met estimate
Average EPS surprise
+1.73%
11 comparable reports
Latest EPS result
-0.24
Estimate -0.32 · Beat by 25.93%

EPS: actual versus estimate

Recent quarterly results

ActualEstimate
Quarterly EPS actual values compared with estimates-0.2-0.29-0.38-0.47Q1 '25BeatQ2 '25MetQ3 '25BeatQ4 '25BeatQ1 '26BeatQ2 '26BeatQ3 '26BeatQ4 '26Estimate
Q1 2025, reported Mar 10, 2025: actual -0.39, estimate -0.4, surprise +2.50%, Beat. Q2 2025, reported May 8, 2025: actual -0.43, estimate -0.43, surprise 0.00%, Met estimate. Q3 2025, reported Aug 12, 2025: actual -0.35, estimate -0.4, surprise +12.50%, Beat. Q4 2025, reported Nov 12, 2025: actual -0.3, estimate -0.36, surprise +16.67%, Beat. Q1 2026, reported Mar 5, 2026: actual -0.28, estimate -0.33, surprise +15.15%, Beat. Q2 2026, reported May 7, 2026: actual -0.26, estimate -0.33, surprise +21.21%, Beat. Q3 2026, reported Aug 13, 2026: actual -0.24, estimate -0.324, surprise +25.93%, Beat. Q4 2026, reported Nov 11, 2026: actual —, estimate -0.29, surprise —, Comparison unavailable.

Revenue: actual versus estimate

Recent quarterly results

ActualEstimate
Quarterly Revenue actual values compared with estimates4.14M3.19M2.25M1.3MQ1 '25MissQ2 '25BeatQ3 '25BeatQ4 '25BeatQ1 '26BeatQ2 '26BeatQ3 '26MissQ4 '26Estimate
Q1 2025, reported Mar 10, 2025: actual 2.08M USD, estimate 2.11M USD, surprise -1.39%, Miss. Q2 2025, reported May 8, 2025: actual 2.35M USD, estimate 1.85M USD, surprise +27.09%, Beat. Q3 2025, reported Aug 12, 2025: actual 2.67M USD, estimate 1.53M USD, surprise +74.09%, Beat. Q4 2025, reported Nov 12, 2025: actual 2.2M USD, estimate 1.96M USD, surprise +12.32%, Beat. Q1 2026, reported Mar 5, 2026: actual 3.94M USD, estimate 2.21M USD, surprise +78.57%, Beat. Q2 2026, reported May 7, 2026: actual 2.4M USD, estimate 2.21M USD, surprise +8.33%, Beat. Q3 2026, reported Aug 13, 2026: actual 1.5M USD, estimate 2.28M USD, surprise -34.23%, Miss. Q4 2026, reported Nov 11, 2026: actual —, estimate 2.18M USD, surprise —, Comparison unavailable.

Analyst ratings

Third-party consensus; not a GoAI recommendation.

Rating distribution

9 ratings
Strong buy00%
Buy9100%
Hold00%
Sell00%
Strong sell00%

CRBU peers

ETFs holding CRBU

Funds reporting this stock among their holdings, ordered by reported position size.

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