
Castle Biosciences, Inc.
CSTLNASDAQHealthcareMedical - Diagnostics & Research
Previous close
$34.20
+$1.27 · +3.86%
CSTL company overview
Regular session · ET · Market data may be delayed.
GoAI snapshot
AI-powered factor overview
GoAI score
Hold
Wait — insufficient conviction to act
Valuation
53
Fair Value
Momentum
38
Weakening
Sentiment
70
Bullish
Risk resilience
34
High Risk
Full GoAI research
Thesis, catalysts, evidence, and risk analysis.
AI-generated, informational only, and not investment advice.
Company profile
Company websiteCastle Biosciences, Inc. functions as a commercial-stage diagnostics firm, with its primary objective being the provision of both diagnostic and prognostic testing services, specifically targeting various dermatological cancers. Their flagship product, DecisionDx-Melanoma, represents an advanced multi-gene expression profile (GEP) assay engineered to assess the probability of metastasis in patients afflicted with invasive cutaneous melanoma. In addition to their leading solution, the company has created several other specialized, proprietary tests. Among these is DecisionDx-UM, a GEP test tailored to forecast the risk of metastasis for individuals with uveal melanoma, a less common malignancy of the eye. Another key offering is DecisionDx-SCC, a distinctive 40-gene expression profile test that utilizes a patient's unique tumor biology to predict their specific risk of squamous cell carcinoma metastasis, particularly for those presenting with recognized risk factors. Moreover, they offer DecisionDx DiffDx-Melanoma and myPath Melanoma, both proprietary GEP tests employed to assist in the accurate diagnosis of ambiguous pigmented lesions. These specialized testing services are provided by Castle Biosciences to patients predominantly through their healthcare providers. The organization commenced operations in 2007 and maintains its corporate headquarters in Friendswood, Texas.
- Industry
- Medical - Diagnostics & Research
- Sector
- Healthcare
- Headquarters
- US
- CEO
- Derek J. Maetzold
- Listed since
- Jul 25, 2019
- Employees
- 1,002
Market position
Day range
Current $34.20
52-week range
Current $34.20
- Open
- $32.695
- Previous close
- $32.93
- Volume
- 573.47K
- 1.37× average
- Average volume
- 418.51K
- Average daily volume
- Market cap
- 1.04B USD
- Beta
- 0.97
- Market reference 1
- 50-day average
- $25.8324
- +32.39% above average
- 200-day average
- $29.4308
- +16.20% above average
Financials
Financial snapshot
Latest / TTMValuation & yield
- Enterprise value
- 1.05B USD
- P/E (TTM)
- -51.86×
- P/B (TTM)
- 2.21×
- P/S (TTM)
- 2.92×
- EV / EBITDA
- 92.37×
- Earnings yield
- -2.14%
- Free cash flow yield
- 2.51%
- Dividend yield
- 0.00%
Profitability & efficiency
- Gross margin
- 77.26%
- Operating margin
- -8.99%
- Net margin
- -5.43%
- Return on equity
- -5.13%
- Return on assets
- -4.18%
- Return on invested capital
- -6.85%
Financial health
- Debt / equity
- 0.08×
- Current ratio
- 5.26×
Financial statements
Margin trends
Profitability as a percentage of reported revenue.
Income trends
Revenue
Operating income
Net income
| Metric (USD) | FY2025 | FY2024 | FY2023 | FY2022 | FY2021 |
|---|---|---|---|---|---|
| Revenue | 344.23M USD | 332.07M USD | 219.79M USD | 137.04M USD | 94.09M USD |
| Cost of goods sold | 71.03M USD | 60.21M USD | 44.98M USD | 32.01M USD | 15.82M USD |
| Gross profit | 273.2M USD | 271.86M USD | 174.81M USD | 105.03M USD | 78.26M USD |
| Research and development | 51.85M USD | 52.04M USD | 53.62M USD | 44.9M USD | 29.65M USD |
| Selling, general, and administrative | 229.32M USD | 200.05M USD | 180.15M USD | 143M USD | 86.74M USD |
| Operating expenses | 316.01M USD | 263.19M USD | 242.78M USD | 177.89M USD | 118.34M USD |
| Interest income | 11.77M USD | 12.92M USD | 10.62M USD | 3.97M USD | 68K USD |
| Interest expense | 86K USD | 577K USD | 11K USD | 17K USD | 1K USD |
| Depreciation and amortization | 40.77M USD | 16M USD | 12.33M USD | 10.54M USD | 3.41M USD |
| Operating income | −42.81M USD | 8.67M USD | −67.98M USD | −72.86M USD | −40.08M USD |
| Net income | −24.16M USD | 18.25M USD | −57.47M USD | −67.14M USD | −31.29M USD |
Company facts updated Aug 24, 2026.
Earnings
- EPS beat rate
- 82%
- 9 beats, 1 miss, 1 met estimate
- Average EPS surprise
- +78.04%
- 11 comparable reports
- Latest EPS result
- -0.07
- Estimate -0.41 · Beat by 82.80%
EPS: actual versus estimate
Recent quarterly results
Revenue: actual versus estimate
Recent quarterly results
Analyst ratings
Third-party consensus; not a GoAI recommendation.
Analyst price target
Average target
$39.00
14.04% upsideRating distribution
11 ratingsCSTL news
CSTL peers
ETFs holding CSTL
Funds reporting this stock among their holdings, ordered by reported position size.
iShares Russell 2000 ETFIWM25.34M0.03%81.62B USD0.19%$299.96+0.77%
Vanguard Morningstar Total Stock Market ETFVTI23.88M0.00%2.3T USD0.03%$378.24+0.44%
Vanguard Extended Market ETFVXF9.74M0.01%93.7B USD0.05%$245.53+0.82%
iShares Russell 2000 Value ETFIWN9.11M0.06%14.66B USD0.24%$224.81+0.45%
iShares Biotechnology ETFIBB7.35M0.07%10.75B USD0.44%$213.56+1.29%
EA Bridgeway Omni Small-Cap Value ETFBSVO4.97M0.20%1.71B USD0.47%$29.62+0.85%
Schwab U.S. Small-Cap ETFSCHA4.73M0.02%23.1B USD0.03%$34.83+0.52%
Vanguard Russell 2000 ETFVTWO4.71M0.03%17.4B USD0.06%$121.25+0.74%
iShares Russell 2000 ETFIWM- Market value
- 25.34M
- Weight
- 0.03%
- AUM
- 81.62B USD
- Expense ratio
- 0.19%
- Price / 1D
- $299.96+0.77%
Vanguard Morningstar Total Stock Market ETFVTI- Market value
- 23.88M
- Weight
- 0.00%
- AUM
- 2.3T USD
- Expense ratio
- 0.03%
- Price / 1D
- $378.24+0.44%
Vanguard Extended Market ETFVXF- Market value
- 9.74M
- Weight
- 0.01%
- AUM
- 93.7B USD
- Expense ratio
- 0.05%
- Price / 1D
- $245.53+0.82%
iShares Russell 2000 Value ETFIWN- Market value
- 9.11M
- Weight
- 0.06%
- AUM
- 14.66B USD
- Expense ratio
- 0.24%
- Price / 1D
- $224.81+0.45%
iShares Biotechnology ETFIBB- Market value
- 7.35M
- Weight
- 0.07%
- AUM
- 10.75B USD
- Expense ratio
- 0.44%
- Price / 1D
- $213.56+1.29%
EA Bridgeway Omni Small-Cap Value ETFBSVO- Market value
- 4.97M
- Weight
- 0.20%
- AUM
- 1.71B USD
- Expense ratio
- 0.47%
- Price / 1D
- $29.62+0.85%
Schwab U.S. Small-Cap ETFSCHA- Market value
- 4.73M
- Weight
- 0.02%
- AUM
- 23.1B USD
- Expense ratio
- 0.03%
- Price / 1D
- $34.83+0.52%
Vanguard Russell 2000 ETFVTWO- Market value
- 4.71M
- Weight
- 0.03%
- AUM
- 17.4B USD
- Expense ratio
- 0.06%
- Price / 1D
- $121.25+0.74%
Continue in GoAI
Research CSTLresearch.disclaimer











