Castle Biosciences, Inc. logo

Castle Biosciences, Inc.

CSTL

NASDAQHealthcareMedical - Diagnostics & Research

Previous close

$34.20

+$1.27 · +3.86%

Aug 21, 4:00 PM ET

CSTL company overview

Regular session · ET · Market data may be delayed.

GoAI snapshot

AI-powered factor overview

Jul 10, 2026

GoAI score

Hold

Wait — insufficient conviction to act

Valuation

53

Fair Value

Momentum

38

Weakening

Sentiment

70

Bullish

Risk resilience

34

High Risk

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Company profile

Company website

Castle Biosciences, Inc. functions as a commercial-stage diagnostics firm, with its primary objective being the provision of both diagnostic and prognostic testing services, specifically targeting various dermatological cancers. Their flagship product, DecisionDx-Melanoma, represents an advanced multi-gene expression profile (GEP) assay engineered to assess the probability of metastasis in patients afflicted with invasive cutaneous melanoma. In addition to their leading solution, the company has created several other specialized, proprietary tests. Among these is DecisionDx-UM, a GEP test tailored to forecast the risk of metastasis for individuals with uveal melanoma, a less common malignancy of the eye. Another key offering is DecisionDx-SCC, a distinctive 40-gene expression profile test that utilizes a patient's unique tumor biology to predict their specific risk of squamous cell carcinoma metastasis, particularly for those presenting with recognized risk factors. Moreover, they offer DecisionDx DiffDx-Melanoma and myPath Melanoma, both proprietary GEP tests employed to assist in the accurate diagnosis of ambiguous pigmented lesions. These specialized testing services are provided by Castle Biosciences to patients predominantly through their healthcare providers. The organization commenced operations in 2007 and maintains its corporate headquarters in Friendswood, Texas.

Industry
Medical - Diagnostics & Research
Sector
Healthcare
Headquarters
US
CEO
Derek J. Maetzold
Listed since
Jul 25, 2019
Employees
1,002

Market position

Day range

Current $34.20

52-week range

Current $34.20

Open
$32.695
Previous close
$32.93
Volume
573.47K
1.37× average
Average volume
418.51K
Average daily volume
Market cap
1.04B USD
Beta
0.97
Market reference 1
50-day average
$25.8324
+32.39% above average
200-day average
$29.4308
+16.20% above average

Financials

Financial snapshot

Latest / TTM

Valuation & yield

Enterprise value
1.05B USD
P/E (TTM)
-51.86×
P/B (TTM)
2.21×
P/S (TTM)
2.92×
EV / EBITDA
92.37×
Earnings yield
-2.14%
Free cash flow yield
2.51%
Dividend yield
0.00%

Profitability & efficiency

Gross margin
77.26%
Operating margin
-8.99%
Net margin
-5.43%
Return on equity
-5.13%
Return on assets
-4.18%
Return on invested capital
-6.85%

Financial health

Debt / equity
0.08×
Current ratio
5.26×

Financial statements

Margin trends

Profitability as a percentage of reported revenue.

Gross marginOperating marginNet margin
Gross, operating, and net margin trends97%42%-12%-67%Gross margin, FY2021: 83.18%Gross margin, FY2022: 76.64%Gross margin, FY2023: 79.53%Gross margin, FY2024: 81.87%Gross margin, FY2025: 79.37%Operating margin, FY2021: -42.60%Operating margin, FY2022: -53.16%Operating margin, FY2023: -30.93%Operating margin, FY2024: 2.61%Operating margin, FY2025: -12.44%Net margin, FY2021: -33.26%Net margin, FY2022: -48.99%Net margin, FY2023: -26.15%Net margin, FY2024: 5.49%Net margin, FY2025: -7.02%FY2021FY2022FY2023FY2024FY2025
Gross margin FY2021 83.18%. Gross margin FY2022 76.64%. Gross margin FY2023 79.53%. Gross margin FY2024 81.87%. Gross margin FY2025 79.37%. Operating margin FY2021 -42.60%. Operating margin FY2022 -53.16%. Operating margin FY2023 -30.93%. Operating margin FY2024 2.61%. Operating margin FY2025 -12.44%. Net margin FY2021 -33.26%. Net margin FY2022 -48.99%. Net margin FY2023 -26.15%. Net margin FY2024 5.49%. Net margin FY2025 -7.02%.

Income trends

Revenue

344.23M USD+3.66%

Operating income

−42.81M USD−51.48M USD

Net income

−24.16M USD−42.4M USD
Income trends across reported periods385.94M USD219.1M USD52.27M USD−114.56M USDRevenue, FY2021: 94.09M USDRevenue, FY2022: 137.04M USDRevenue, FY2023: 219.79M USDRevenue, FY2024: 332.07M USDRevenue, FY2025: 344.23M USDOperating income, FY2021: −40.08M USDOperating income, FY2022: −72.86M USDOperating income, FY2023: −67.98M USDOperating income, FY2024: 8.67M USDOperating income, FY2025: −42.81M USDNet income, FY2021: −31.29M USDNet income, FY2022: −67.14M USDNet income, FY2023: −57.47M USDNet income, FY2024: 18.25M USDNet income, FY2025: −24.16M USDFY2021FY2022FY2023FY2024FY2025
Revenue FY2021 94.09M USD. Revenue FY2022 137.04M USD. Revenue FY2023 219.79M USD. Revenue FY2024 332.07M USD. Revenue FY2025 344.23M USD. Operating income FY2021 −40.08M USD. Operating income FY2022 −72.86M USD. Operating income FY2023 −67.98M USD. Operating income FY2024 8.67M USD. Operating income FY2025 −42.81M USD. Net income FY2021 −31.29M USD. Net income FY2022 −67.14M USD. Net income FY2023 −57.47M USD. Net income FY2024 18.25M USD. Net income FY2025 −24.16M USD.
Metric (USD)FY2025FY2024FY2023FY2022FY2021
Revenue344.23M USD332.07M USD219.79M USD137.04M USD94.09M USD
Cost of goods sold71.03M USD60.21M USD44.98M USD32.01M USD15.82M USD
Gross profit273.2M USD271.86M USD174.81M USD105.03M USD78.26M USD
Research and development51.85M USD52.04M USD53.62M USD44.9M USD29.65M USD
Selling, general, and administrative229.32M USD200.05M USD180.15M USD143M USD86.74M USD
Operating expenses316.01M USD263.19M USD242.78M USD177.89M USD118.34M USD
Interest income11.77M USD12.92M USD10.62M USD3.97M USD68K USD
Interest expense86K USD577K USD11K USD17K USD1K USD
Depreciation and amortization40.77M USD16M USD12.33M USD10.54M USD3.41M USD
Operating income−42.81M USD8.67M USD−67.98M USD−72.86M USD−40.08M USD
Net income−24.16M USD18.25M USD−57.47M USD−67.14M USD−31.29M USD

Company facts updated Aug 24, 2026.

Earnings

EPS beat rate
82%
9 beats, 1 miss, 1 met estimate
Average EPS surprise
+78.04%
11 comparable reports
Latest EPS result
-0.07
Estimate -0.41 · Beat by 82.80%

EPS: actual versus estimate

Recent quarterly results

ActualEstimate
Quarterly EPS actual values compared with estimates0.42-0.05-0.53-1Q1 '25BeatQ2 '25MissQ3 '25BeatQ4 '25BeatQ1 '26BeatQ2 '26MetQ3 '26BeatQ4 '26Estimate
Q1 2025, reported Feb 27, 2025: actual 0.32, estimate -0.04, surprise +900.00%, Beat. Q2 2025, reported May 5, 2025: actual -0.9, estimate -0.08, surprise -1025.00%, Miss. Q3 2025, reported Aug 4, 2025: actual 0.15, estimate -0.51, surprise +129.41%, Beat. Q4 2025, reported Nov 3, 2025: actual -0.02, estimate -0.34, surprise +94.12%, Beat. Q1 2026, reported Feb 26, 2026: actual -0.08, estimate -0.23, surprise +65.22%, Beat. Q2 2026, reported May 6, 2026: actual -0.49, estimate -0.49, surprise 0.00%, Met estimate. Q3 2026, reported Jul 30, 2026: actual -0.07, estimate -0.407, surprise +82.80%, Beat. Q4 2026, reported Nov 2, 2026: actual —, estimate -0.38, surprise —, Comparison unavailable.

Revenue: actual versus estimate

Recent quarterly results

ActualEstimate
Quarterly Revenue actual values compared with estimates107.69M93.08M78.47M63.86MQ1 '25BeatQ2 '25BeatQ3 '25BeatQ4 '25BeatQ1 '26BeatQ2 '26BeatQ3 '26BeatQ4 '26Estimate
Q1 2025, reported Feb 27, 2025: actual 86.31M USD, estimate 83.89M USD, surprise +2.89%, Beat. Q2 2025, reported May 5, 2025: actual 87.2M USD, estimate 80.31M USD, surprise +8.57%, Beat. Q3 2025, reported Aug 4, 2025: actual 86.19M USD, estimate 68M USD, surprise +26.75%, Beat. Q4 2025, reported Nov 3, 2025: actual 83.04M USD, estimate 80.38M USD, surprise +3.31%, Beat. Q1 2026, reported Feb 26, 2026: actual 87.01M USD, estimate 79.89M USD, surprise +8.91%, Beat. Q2 2026, reported May 6, 2026: actual 84.23M USD, estimate 79.23M USD, surprise +6.31%, Beat. Q3 2026, reported Jul 30, 2026: actual 103.55M USD, estimate 86.23M USD, surprise +20.07%, Beat. Q4 2026, reported Nov 2, 2026: actual —, estimate 92.13M USD, surprise —, Comparison unavailable.

Analyst ratings

Third-party consensus; not a GoAI recommendation.

Analyst price target

Average target

$39.00

14.04% upside
Past 12 months12-month forecastHigh $44.00Average $39.00Low $35.00

Rating distribution

11 ratings
Strong buy00%
Buy11100%
Hold00%
Sell00%
Strong sell00%

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