Karyopharm Therapeutics Inc. (KPTI) stock price, financials & research | GoAI

Regular session · ET · Market data may be delayed.

GoAI snapshot

Jul 10, 2026

54/ 100

GoAI Score

Hold

Valuation

51

Fair Value

Sentiment

69

Bullish

Risk

45

Elevated Risk

Momentum

69

Gaining

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Company profile

Industry: Biotechnology
Sector: Healthcare
Headquarters: US

Market position

Day range

Current $1.61

$1.24$1.61

52-week range

Current $1.61

$1.24$10.99

Open: $1.50
Previous close: $1.62
Volume: 6.73M
Market cap: 36.49M USD
50-day average: $4.7773; -66.30% below average
200-day average: $7.0737; -77.24% below average

Financials

Financial snapshot

Latest / TTM

Valuation & yield

P/E (TTM): -0.07×
P/B (TTM): -0.14×
P/S (TTM): 0.25×
Dividend yield: 0.00%

Profitability & efficiency

Gross margin: 95.88%
Operating margin: -56.17%
Net margin: -153.28%

Financial health

Debt / equity: -0.65×

Financial statements

Margin trends

Profitability as a percentage of reported revenue.

Gross marginOperating marginNet margin

Income trends

Revenue

146.07M USD+0.57%

Operating income

−90.71M USD+24.06%

Net income

−196.04M USD-156.52%

Financial statements: Income statement
Metric (USD)	FY2025	FY2024	FY2023	FY2022	FY2021
Revenue	146.07M USD	145.24M USD	146.03M USD	157.07M USD	209.82M USD
Cost of goods sold	5.95M USD	6.01M USD	4.94M USD	5.21M USD	3.4M USD
Gross profit	140.12M USD	139.23M USD	141.09M USD	151.86M USD	206.42M USD
Research and development	125.62M USD	143.23M USD	138.75M USD	148.66M USD	160.84M USD
Selling, general, and administrative	105.21M USD	115.44M USD	131.88M USD	145.4M USD	143.85M USD
Operating expenses	230.83M USD	258.67M USD	270.63M USD	294.06M USD	304.69M USD
Interest income	2.77M USD	7.4M USD	10.94M USD	2.36M USD	582K USD
Interest expense	45.85M USD	37.42M USD	23.82M USD	25M USD	26.05M USD
Depreciation and amortization	296K USD	340K USD	530K USD	621K USD	789K USD
Operating income	−90.71M USD	−119.44M USD	−129.54M USD	−142.2M USD	−98.27M USD
Net income	−196.04M USD	−76.42M USD	−143.1M USD	−165.29M USD	−124.09M USD

Company facts updated Sep 12, 2026.

Earnings

EPS beat rate: 45%; 5 beats, 6 misses, 0 met estimates
Average EPS surprise: -285.69%; 11 comparable reports
Latest EPS result: -2.32; Estimate -1.37 · Miss by 69.34%

EPS: actual versus estimate

Recent quarterly results

ActualEstimate

Revenue: actual versus estimate

Recent quarterly results

ActualEstimate

KPTI peers

Amgen Inc.

AMGN

Amgen Inc.

$377.35

-1.34%

Gilead Sciences, Inc.

GILD

Gilead Sciences, Inc.

$143.72

-0.75%

Vertex Pharmaceuticals Incorporated

VRTX

Vertex Pharmaceuticals Incorporated

$515.44

+0.17%

Intuitive Surgical, Inc.

ISRG

Intuitive Surgical, Inc.

$369.15

+2.41%

Sanofi

SNY

Sanofi

$42.77

+0.12%

Regeneron Pharmaceuticals, Inc.

REGN

Regeneron Pharmaceuticals, Inc.

$781.49

-1.48%

ETFs holding KPTI

Funds reporting this stock among their holdings, ordered by reported position size.

ETFMarket valueWeightAUMExpense ratioPrice / 1D

Vanguard Morningstar Total Stock Market ETF

Vanguard Morningstar Total Stock Market ETFVTI1.3M0.00%2.3T USD0.03%$376.31+0.82%

iShares Russell 2000 ETF

iShares Russell 2000 ETFIWM808.48K0.00%77.55B USD0.19%$288.89+0.41%

Vanguard Extended Market ETF

Vanguard Extended Market ETFVXF505.12K0.00%93.7B USD0.05%$237.76+0.68%

Fidelity Enhanced Small Cap ETF

Fidelity Enhanced Small Cap ETFFESM284.49K—6.49B USD0.28%$46.36+0.78%

iShares Russell 2000 Value ETF

iShares Russell 2000 Value ETFIWN257.7K0.00%14.28B USD0.24%$219.69+0.33%

Vanguard Russell 2000 ETF

Vanguard Russell 2000 ETFVTWO214.09K0.00%17.4B USD0.06%$116.76+0.36%

iShares Micro-Cap ETF

iShares Micro-Cap ETFIWC112.38K0.01%1.44B USD0.60%$190.84+0.39%

Invesco Russell 2000 Dynamic Multifactor ETF

Invesco Russell 2000 Dynamic Multifactor ETFOMFS58.15K0.02%276.02M USD0.39%$51.57+0.33%

Vanguard Morningstar Total Stock Market ETF

Vanguard Morningstar Total Stock Market ETFVTI

Market value: 1.3M
Weight: 0.00%
AUM: 2.3T USD
Expense ratio: 0.03%
Price / 1D: $376.31+0.82%

iShares Russell 2000 ETF

iShares Russell 2000 ETFIWM

Market value: 808.48K
Weight: 0.00%
AUM: 77.55B USD
Expense ratio: 0.19%
Price / 1D: $288.89+0.41%

Vanguard Extended Market ETF

Vanguard Extended Market ETFVXF

Market value: 505.12K
Weight: 0.00%
AUM: 93.7B USD
Expense ratio: 0.05%
Price / 1D: $237.76+0.68%

Fidelity Enhanced Small Cap ETF

Fidelity Enhanced Small Cap ETFFESM

Market value: 284.49K
Weight: —
AUM: 6.49B USD
Expense ratio: 0.28%
Price / 1D: $46.36+0.78%

iShares Russell 2000 Value ETF

iShares Russell 2000 Value ETFIWN

Market value: 257.7K
Weight: 0.00%
AUM: 14.28B USD
Expense ratio: 0.24%
Price / 1D: $219.69+0.33%

Vanguard Russell 2000 ETF

Vanguard Russell 2000 ETFVTWO

Market value: 214.09K
Weight: 0.00%
AUM: 17.4B USD
Expense ratio: 0.06%
Price / 1D: $116.76+0.36%

iShares Micro-Cap ETF

iShares Micro-Cap ETFIWC

Market value: 112.38K
Weight: 0.01%
AUM: 1.44B USD
Expense ratio: 0.60%
Price / 1D: $190.84+0.39%

Invesco Russell 2000 Dynamic Multifactor ETF

Invesco Russell 2000 Dynamic Multifactor ETFOMFS

Market value: 58.15K
Weight: 0.02%
AUM: 276.02M USD
Expense ratio: 0.39%
Price / 1D: $51.57+0.33%

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AI-generated and delayed market data for informational and educational purposes only. Not investment advice.