OPKO Health, Inc. logo

OPKO Health, Inc.

OPK

NASDAQHealthcareMedical - Diagnostics & Research

Regular session

$1.495

+$0.015 · +1.01%

Aug 24, 11:18 AM ET

OPK company overview

Regular session · ET · Market data may be delayed.

GoAI snapshot

AI-powered factor overview

Jul 10, 2026

GoAI score

Sell

Trim exposure — unfavorable risk-reward

Valuation

42

Fair Value

Momentum

48

Neutral

Sentiment

41

Mixed

Risk resilience

52

Elevated Risk

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Company profile

Company website

OPKO Health, Inc. operates as a healthcare enterprise with a dual focus on diagnostics and pharmaceuticals. Its operations span the United States, Ireland, Chile, Spain, Israel, Mexico, and other international markets. The company's Diagnostics division encompasses BioReference Laboratories, which delivers a comprehensive suite of laboratory testing services. These services are crucial for disease detection, diagnosis, evaluation, monitoring, and treatment, covering areas such as esoteric testing, molecular diagnostics, anatomical pathology, genetics, women's health, and correctional healthcare. BioReference serves a diverse client base, including medical practices, clinics, hospitals, employers, and government entities. Additionally, this segment provides a cutting-edge diagnostic instrument system designed for immediate, point-of-care blood test results, alongside its specialized 4Kscore testing for prostate cancer. Within the Pharmaceutical segment, OPKO offers a range of therapeutic products and a robust development pipeline. Key offerings include Rayaldee, indicated for the management of secondary hyperparathyroidism in adults suffering from stage 3 or 4 chronic kidney disease and vitamin D insufficiency. The pipeline features OPK88004, an investigational orally administered selective androgen receptor modulator; OPK88003, a peptide administered once weekly currently in Phase IIb trials for the treatment of type 2 diabetes and obesity; and hGH-CTP, a once-weekly human growth hormone injection that has successfully completed Phase III clinical trials in collaboration with Pfizer, Inc. A core strategy for this segment involves the development and commercialization of proprietary, extended-release versions of existing therapeutic proteins. Furthermore, OPKO Health supplies specialty active pharmaceutical ingredients (APIs) and is involved in the development, manufacturing, marketing, and sale of pharmaceutical, nutraceutical, veterinary, and ophthalmic products. The company also commercializes food supplements and over-the-counter products, produces and sells items primarily within the generics market, and handles the import, marketing, distribution, and sales of pharmaceutical products across various therapeutic areas, including cardiovascular conditions, vaccines, antibiotics, gastro-intestinal ailments, and hormone-related treatments, among others. Its pharmaceutical operations are further bolstered by platforms situated in Ireland, Chile, Spain, and Mexico. Founded in 1991, OPKO Health, Inc. maintains its corporate headquarters in Miami, Florida.

Industry
Medical - Diagnostics & Research
Sector
Healthcare
Headquarters
US
CEO
Phillip Frost
Listed since
Nov 2, 1995
Employees
2,275

Market position

Day range

Current $1.495

52-week range

Current $1.495

Open
$1.49
Previous close
$1.48
Volume
780.3K
0.24× average
Average volume
3.2M
Average daily volume
Market cap
1.12B USD
Beta
1.49
Market reference 1
50-day average
$1.3754
+8.70% above average
200-day average
$1.2851
+16.33% above average

Financials

Financial snapshot

Latest / TTM

Valuation & yield

P/E (TTM)
-15.69×
P/B (TTM)
0.95×
P/S (TTM)
1.9×
Dividend yield
0.00%

Profitability & efficiency

Gross margin
30.98%
Operating margin
-25.49%
Net margin
-12.40%

Financial health

Debt / equity
0.33×

Financial statements

Margin trends

Profitability as a percentage of reported revenue.

Gross marginOperating marginNet margin
Gross, operating, and net margin trends52%19%-13%-45%Gross margin, FY2021: 32.77%Gross margin, FY2022: 28.70%Gross margin, FY2023: 36.84%Gross margin, FY2024: 43.61%Gross margin, FY2025: 21.10%Operating margin, FY2021: 1.06%Operating margin, FY2022: -22.53%Operating margin, FY2023: -18.18%Operating margin, FY2024: -21.32%Operating margin, FY2025: -36.08%Net margin, FY2021: -1.70%Net margin, FY2022: -32.70%Net margin, FY2023: -21.87%Net margin, FY2024: -7.46%Net margin, FY2025: -37.19%FY2021FY2022FY2023FY2024FY2025
Gross margin FY2021 32.77%. Gross margin FY2022 28.70%. Gross margin FY2023 36.84%. Gross margin FY2024 43.61%. Gross margin FY2025 21.10%. Operating margin FY2021 1.06%. Operating margin FY2022 -22.53%. Operating margin FY2023 -18.18%. Operating margin FY2024 -21.32%. Operating margin FY2025 -36.08%. Net margin FY2021 -1.70%. Net margin FY2022 -32.70%. Net margin FY2023 -21.87%. Net margin FY2024 -7.46%. Net margin FY2025 -37.19%.

Income trends

Revenue

606.88M USD-14.90%

Operating income

−218.99M USD-44.01%

Net income

−225.68M USD-324.02%
Income trends across reported periods1.99B USD1.14B USD302.53M USD−538.72M USDRevenue, FY2021: 1.77B USDRevenue, FY2022: 1B USDRevenue, FY2023: 863.5M USDRevenue, FY2024: 713.14M USDRevenue, FY2025: 606.88M USDOperating income, FY2021: 18.75M USDOperating income, FY2022: −226.25M USDOperating income, FY2023: −157.02M USDOperating income, FY2024: −152.07M USDOperating income, FY2025: −218.99M USDNet income, FY2021: −30.14M USDNet income, FY2022: −328.41M USDNet income, FY2023: −188.86M USDNet income, FY2024: −53.22M USDNet income, FY2025: −225.68M USDFY2021FY2022FY2023FY2024FY2025
Revenue FY2021 1.77B USD. Revenue FY2022 1B USD. Revenue FY2023 863.5M USD. Revenue FY2024 713.14M USD. Revenue FY2025 606.88M USD. Operating income FY2021 18.75M USD. Operating income FY2022 −226.25M USD. Operating income FY2023 −157.02M USD. Operating income FY2024 −152.07M USD. Operating income FY2025 −218.99M USD. Net income FY2021 −30.14M USD. Net income FY2022 −328.41M USD. Net income FY2023 −188.86M USD. Net income FY2024 −53.22M USD. Net income FY2025 −225.68M USD.
Metric (USD)FY2025FY2024FY2023FY2022FY2021
Revenue606.88M USD713.14M USD863.5M USD1B USD1.77B USD
Cost of goods sold478.83M USD402.11M USD545.37M USD715.98M USD1.19B USD
Gross profit128.05M USD311.03M USD318.13M USD288.22M USD581.52M USD
Research and development124.03M USD105.21M USD89.59M USD73.89M USD76.85M USD
Selling, general, and administrative223M USD304.22M USD300.56M USD372.67M USD468.86M USD
Operating expenses347.04M USD463.1M USD475.15M USD514.47M USD562.77M USD
Interest income14.81M USD8.43M USD3.98M USD1.98M USD28K USD
Interest expense108.46M USD47.47M USD13.51M USD12.06M USD18.88M USD
Depreciation and amortization91.63M USD98.18M USD105.3M USD108.66M USD78.72M USD
Operating income−218.99M USD−152.07M USD−157.02M USD−226.25M USD18.75M USD
Net income−225.68M USD−53.22M USD−188.86M USD−328.41M USD−30.14M USD

Company facts updated Aug 24, 2026.

Earnings

EPS beat rate
55%
6 beats, 3 misses, 2 met estimates
Average EPS surprise
+50.31%
11 comparable reports
Latest EPS result
-0.01
Estimate -0.08 · Beat by 87.50%

EPS: actual versus estimate

Recent quarterly results

ActualEstimate
Quarterly EPS actual values compared with estimates0.07-0.03-0.13-0.23Q1 '25BeatQ2 '25MissQ3 '25MissQ4 '25BeatQ1 '26BeatQ2 '26MetQ3 '26BeatQ4 '26Estimate
Q1 2025, reported Feb 27, 2025: actual 0.01, estimate -0.08, surprise +112.50%, Beat. Q2 2025, reported Apr 30, 2025: actual -0.1, estimate -0.06, surprise -66.67%, Miss. Q3 2025, reported Jul 31, 2025: actual -0.19, estimate -0.12, surprise -58.33%, Miss. Q4 2025, reported Oct 29, 2025: actual 0.03, estimate -0.02, surprise +250.00%, Beat. Q1 2026, reported Feb 26, 2026: actual -0.04, estimate -0.07, surprise +42.86%, Beat. Q2 2026, reported Apr 28, 2026: actual -0.07, estimate -0.07, surprise 0.00%, Met estimate. Q3 2026, reported Jul 27, 2026: actual -0.01, estimate -0.08, surprise +87.50%, Beat. Q4 2026, reported Nov 4, 2026: actual —, estimate -0.06, surprise —, Comparison unavailable.

Revenue: actual versus estimate

Recent quarterly results

ActualEstimate
Quarterly Revenue actual values compared with estimates190.98M166.27M141.56M116.85MQ1 '25BeatQ2 '25MissQ3 '25MissQ4 '25BeatQ1 '26BeatQ2 '26MissQ3 '26BeatQ4 '26Estimate
Q1 2025, reported Feb 27, 2025: actual 183.64M USD, estimate 155.42M USD, surprise +18.16%, Beat. Q2 2025, reported Apr 30, 2025: actual 149.95M USD, estimate 165.7M USD, surprise -9.50%, Miss. Q3 2025, reported Jul 31, 2025: actual 156.81M USD, estimate 165.74M USD, surprise -5.39%, Miss. Q4 2025, reported Oct 29, 2025: actual 151.67M USD, estimate 139.76M USD, surprise +8.52%, Beat. Q1 2026, reported Feb 26, 2026: actual 148.5M USD, estimate 139.76M USD, surprise +6.26%, Beat. Q2 2026, reported Apr 28, 2026: actual 124.2M USD, estimate 130.51M USD, surprise -4.84%, Miss. Q3 2026, reported Jul 27, 2026: actual 163.5M USD, estimate 131.23M USD, surprise +24.59%, Beat. Q4 2026, reported Nov 4, 2026: actual —, estimate 136.62M USD, surprise —, Comparison unavailable.

Analyst ratings

Third-party consensus; not a GoAI recommendation.

Rating distribution

13 ratings
Strong buy00%
Buy862%
Hold431%
Sell18%
Strong sell00%

OPK peers

ETFs holding OPK

Funds reporting this stock among their holdings, ordered by reported position size.

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