Personalis, Inc. logo

Personalis, Inc.

PSNL

NASDAQHealthcareMedical - Diagnostics & Research

Previous close

$18.38

+$1.50 · +8.89%

Aug 21, 4:00 PM ET

PSNL company overview

Regular session · ET · Market data may be delayed.

GoAI snapshot

AI-powered factor overview

Jul 10, 2026

GoAI score

Sell

Trim exposure — unfavorable risk-reward

Valuation

24

Expensive

Momentum

75

Gaining

Sentiment

51

Mixed

Risk resilience

44

Elevated Risk

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Company profile

Company website

Personalis, Inc. operates globally as a specialized cancer genomics firm. The company delivers advanced sequencing and data analysis capabilities, primarily supporting the development of novel cancer treatments and facilitating extensive genetic research initiatives. Central to their offerings is the NeXT Platform, which enables detailed data analysis of tumors and their surrounding immune microenvironments, even from small tissue or plasma samples. This platform encompasses several specialized solutions: ImmunoID Next for tissue-based tumor profiling; NeXT Liquid Biopsy for plasma analysis; NeXT Personal, a specific liquid biopsy designed for individual patient tumor tracking; the NeXT Dx Test, a genomic cancer profiling tool that identifies composite biomarkers for treatment guidance; and the sophisticated NeXT SHERPA and NeXT NEOPS for predicting neoantigens. Additionally, Personalis offers the ACE platform, utilized for diverse clinical and therapeutic applications like neoantigen prediction, biomarker identification, and the selection of new drug targets. Their clientele includes biopharmaceutical companies, academic institutions, non-profit organizations, and government entities. The company has established significant partnerships with organizations such as Mayo Clinic, MapKure, LLC, SpringWorks Therapeutics, Inc., and Moores Cancer Center. Personalis, Inc. was founded in 2011 and is based in Menlo Park, California.

Industry
Medical - Diagnostics & Research
Sector
Healthcare
Headquarters
US
CEO
Christopher Hall
Listed since
Jun 20, 2019
Employees
260

Market position

Day range

Current $18.38

52-week range

Current $18.38

Open
$16.655
Previous close
$16.88
Volume
8M
2.2× average
Average volume
3.63M
Average daily volume
Market cap
1.96B USD
Beta
2.29
Market reference 1
50-day average
$13.1958
+39.29% above average
200-day average
$9.4277
+94.96% above average

Financials

Financial snapshot

Latest / TTM

Valuation & yield

Enterprise value
626.06M USD
P/E (TTM)
-16.86×
P/B (TTM)
8.24×
P/S (TTM)
28.16×
EV / EBITDA
-8.82×
Earnings yield
-11.44%
Free cash flow yield
-11.18%
Dividend yield
0.00%

Profitability & efficiency

Gross margin
12.69%
Operating margin
-164.07%
Net margin
-153.84%
Return on equity
-31.12%
Return on assets
-24.32%
Return on invested capital
-29.10%

Financial health

Debt / equity
0.16×
Current ratio
6.76×
Altman Z-score
12.04
Piotroski F-score
1 of 9

Financial statements

Margin trends

Profitability as a percentage of reported revenue.

Gross marginOperating marginNet margin
Gross, operating, and net margin trends58%-27%-113%-199%Gross margin, FY2021: 37.03%Gross margin, FY2022: 20.52%Gross margin, FY2023: 24.78%Gross margin, FY2024: 31.70%Gross margin, FY2025: 22.65%Operating margin, FY2021: -76.44%Operating margin, FY2022: -177.61%Operating margin, FY2023: -131.05%Operating margin, FY2024: -80.68%Operating margin, FY2025: -126.43%Net margin, FY2021: -76.29%Net margin, FY2022: -174.20%Net margin, FY2023: -147.38%Net margin, FY2024: -96.06%Net margin, FY2025: -116.69%FY2021FY2022FY2023FY2024FY2025
Gross margin FY2021 37.03%. Gross margin FY2022 20.52%. Gross margin FY2023 24.78%. Gross margin FY2024 31.70%. Gross margin FY2025 22.65%. Operating margin FY2021 -76.44%. Operating margin FY2022 -177.61%. Operating margin FY2023 -131.05%. Operating margin FY2024 -80.68%. Operating margin FY2025 -126.43%. Net margin FY2021 -76.29%. Net margin FY2022 -174.20%. Net margin FY2023 -147.38%. Net margin FY2024 -96.06%. Net margin FY2025 -116.69%.

Income trends

Revenue

69.65M USD-17.69%

Operating income

−88.06M USD-28.99%

Net income

−81.27M USD+0.02%
Income trends across reported periods105.6M USD25.19M USD−55.22M USD−135.63M USDRevenue, FY2021: 85.49M USDRevenue, FY2022: 65.05M USDRevenue, FY2023: 73.48M USDRevenue, FY2024: 84.61M USDRevenue, FY2025: 69.65M USDOperating income, FY2021: −65.35M USDOperating income, FY2022: −115.53M USDOperating income, FY2023: −96.29M USDOperating income, FY2024: −68.27M USDOperating income, FY2025: −88.06M USDNet income, FY2021: −65.23M USDNet income, FY2022: −113.32M USDNet income, FY2023: −108.3M USDNet income, FY2024: −81.28M USDNet income, FY2025: −81.27M USDFY2021FY2022FY2023FY2024FY2025
Revenue FY2021 85.49M USD. Revenue FY2022 65.05M USD. Revenue FY2023 73.48M USD. Revenue FY2024 84.61M USD. Revenue FY2025 69.65M USD. Operating income FY2021 −65.35M USD. Operating income FY2022 −115.53M USD. Operating income FY2023 −96.29M USD. Operating income FY2024 −68.27M USD. Operating income FY2025 −88.06M USD. Net income FY2021 −65.23M USD. Net income FY2022 −113.32M USD. Net income FY2023 −108.3M USD. Net income FY2024 −81.28M USD. Net income FY2025 −81.27M USD.
Metric (USD)FY2025FY2024FY2023FY2022FY2021
Revenue69.65M USD84.61M USD73.48M USD65.05M USD85.49M USD
Cost of goods sold53.87M USD57.79M USD55.27M USD51.7M USD53.84M USD
Gross profit15.78M USD26.83M USD18.21M USD13.35M USD31.66M USD
Research and development50.26M USD48.91M USD64.78M USD64.91M USD49.31M USD
Selling, general, and administrative53.57M USD46.19M USD49.73M USD63.97M USD47.7M USD
Operating expenses103.83M USD95.09M USD114.5M USD128.88M USD97.01M USD
Interest income7.16M USD5.51M USD5.9M USD2.4M USD367K USD
Interest expense205K USD24K USD110K USD201K USD184K USD
Depreciation and amortization10.05M USD10.94M USD11.3M USD8.43M USD6.01M USD
Operating income−88.06M USD−68.27M USD−96.29M USD−115.53M USD−65.35M USD
Net income−81.27M USD−81.28M USD−108.3M USD−113.32M USD−65.23M USD

Company facts updated Aug 24, 2026.

Earnings

EPS beat rate
73%
8 beats, 3 misses, 0 met estimates
Average EPS surprise
+3.44%
11 comparable reports
Latest EPS result
-0.3
Estimate -0.26 · Miss by 13.93%

EPS: actual versus estimate

Recent quarterly results

ActualEstimate
Quarterly EPS actual values compared with estimates-0.15-0.22-0.29-0.36Q1 '25BeatQ2 '25BeatQ3 '25BeatQ4 '25BeatQ1 '26BeatQ2 '26MissQ3 '26MissQ4 '26Estimate
Q1 2025, reported Feb 27, 2025: actual -0.23, estimate -0.32, surprise +28.13%, Beat. Q2 2025, reported May 6, 2025: actual -0.18, estimate -0.23, surprise +21.74%, Beat. Q3 2025, reported Aug 5, 2025: actual -0.23, estimate -0.25, surprise +8.00%, Beat. Q4 2025, reported Nov 4, 2025: actual -0.24, estimate -0.28, surprise +14.29%, Beat. Q1 2026, reported Feb 26, 2026: actual -0.26, estimate -0.31, surprise +16.13%, Beat. Q2 2026, reported May 7, 2026: actual -0.29, estimate -0.23, surprise -26.09%, Miss. Q3 2026, reported Aug 4, 2026: actual -0.3, estimate -0.263, surprise -13.93%, Miss. Q4 2026, reported Nov 3, 2026: actual —, estimate -0.26, surprise —, Comparison unavailable.

Revenue: actual versus estimate

Recent quarterly results

ActualEstimate
Quarterly Revenue actual values compared with estimates23.25M20.03M16.81M13.59MQ1 '25BeatQ2 '25BeatQ3 '25MissQ4 '25MissQ1 '26BeatQ2 '26BeatQ3 '26BeatQ4 '26Estimate
Q1 2025, reported Feb 27, 2025: actual 16.8M USD, estimate 15.48M USD, surprise +8.56%, Beat. Q2 2025, reported May 6, 2025: actual 20.61M USD, estimate 17.41M USD, surprise +18.32%, Beat. Q3 2025, reported Aug 5, 2025: actual 17.2M USD, estimate 20.12M USD, surprise -14.48%, Miss. Q4 2025, reported Nov 4, 2025: actual 14.5M USD, estimate 17.04M USD, surprise -14.94%, Miss. Q1 2026, reported Feb 26, 2026: actual 17.35M USD, estimate 17.05M USD, surprise +1.73%, Beat. Q2 2026, reported May 7, 2026: actual 15.47M USD, estimate 14.49M USD, surprise +6.81%, Beat. Q3 2026, reported Aug 4, 2026: actual 22.36M USD, estimate 16.69M USD, surprise +33.97%, Beat. Q4 2026, reported Nov 3, 2026: actual —, estimate 21.35M USD, surprise —, Comparison unavailable.

Analyst ratings

Third-party consensus; not a GoAI recommendation.

Analyst price target

Average target

$14.63

20.40% downside
Past 12 months12-month forecastHigh $17.00Average $14.63Low $9.00

Rating distribution

12 ratings
Strong buy00%
Buy975%
Hold325%
Sell00%
Strong sell00%

Recent analyst actions

6 institutions

PSNL peers

ETFs holding PSNL

Funds reporting this stock among their holdings, ordered by reported position size.

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