Seres Therapeutics, Inc. logo

Seres Therapeutics, Inc.

MCRB

NASDAQHealthcareBiotechnology

Previous close

$4.56

−$0.01 · -0.22%

Aug 21, 4:00 PM ET

MCRB company overview

Historical prices · Market data may be delayed.

GoAI snapshot

AI-powered factor overview

Jul 10, 2026

GoAI score

Sell

Trim exposure — unfavorable risk-reward

Valuation

2

Overpriced

Momentum

25

Weakening

Sentiment

66

Bullish

Risk resilience

34

High Risk

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Company profile

Company website

Seres Therapeutics, Inc. is a pioneering microbiome therapeutics firm dedicated to engineering bacterial consortia that modulate host cells and tissues to combat various diseases. Their flagship therapeutic, SER-109, an oral microbiome treatment, has successfully concluded Phase III clinical trials for the management of Clostridioides difficile infection (CDI). The company's pipeline further encompasses SER-155, a synthetically cultured bacterial formulation currently undergoing Phase Ib evaluation. This candidate aims to mitigate the risk of gastrointestinal and bloodstream infections, alongside graft-versus-host disease, in vulnerable patients undergoing allogeneic hematopoietic stem cell or solid organ transplantation. Additionally, Seres Therapeutics is advancing SER-287 and SER-301, both in Phase Ib for ulcerative colitis, as well as SER-401, which targets metastatic melanoma, and SER-262, also directed at Clostridioides difficile infection. Seres maintains strategic alliances through licensing and collaboration agreements with entities such as Nestec Ltd. and Memorial Sloan Kettering Cancer Center. Established in 2010, the company previously operated as Seres Health, Inc. before adopting its current name in May 2015, and it maintains its principal offices in Cambridge, Massachusetts.

Industry
Biotechnology
Sector
Healthcare
Headquarters
US
CEO
Richard N. Kender
Listed since
Jun 26, 2015
Employees
66

Market position

Day range

Current $4.56

52-week range

Current $4.56

Open
$4.53
Previous close
$4.57
Volume
45.42K
0.58× average
Average volume
78.35K
Average daily volume
Market cap
44.16M USD
Beta
0.21
Market reference 1
50-day average
$5.7188
-20.26% below average
200-day average
$10.2704
-55.60% below average

Financials

Financial snapshot

Latest / TTM

Valuation & yield

P/E (TTM)
-1.88×
P/B (TTM)
1.27×
P/S (TTM)
23.45×
Dividend yield
0.00%

Profitability & efficiency

Gross margin
82.58%
Operating margin
-4462.77%
Net margin
-1192.94%

Financial health

Debt / equity
1.64×
Altman Z-score
-14.5
Piotroski F-score
3 of 9

Financial statements

Margin trends

Profitability as a percentage of reported revenue.

Gross marginOperating marginNet margin
Gross, operating, and net margin trends1985%-3068%-8121%-13173%Gross margin, FY2021: 100.00%Gross margin, FY2025: -423.83%Operating margin, FY2021: -44.50%Operating margin, FY2025: -11910.14%Net margin, FY2021: -45.25%Net margin, FY2025: 721.93%FY2021FY2022FY2023FY2024FY2025
Gross margin FY2021 100.00%. Gross margin FY2025 -423.83%. Operating margin FY2021 -44.50%. Operating margin FY2025 -11910.14%. Net margin FY2021 -45.25%. Net margin FY2025 721.93%.

Income trends

Revenue

789K USD-99.46%

Operating income

−93.97M USD+22.54%

Net income

5.7M USD+152.27M USD
Income trends across reported periods184.44M USD26.4M USD−131.63M USD−289.67M USDRevenue, FY2021: 144.93M USDRevenue, FY2025: 789K USDOperating income, FY2021: −64.49M USDOperating income, FY2022: −179.91M USDOperating income, FY2023: −195.1M USDOperating income, FY2024: −121.32M USDOperating income, FY2025: −93.97M USDNet income, FY2021: −65.58M USDNet income, FY2022: −250.16M USDNet income, FY2023: −113.72M USDNet income, FY2024: −146.57M USDNet income, FY2025: 5.7M USDFY2021FY2022FY2023FY2024FY2025
Revenue FY2021 144.93M USD. Revenue FY2025 789K USD. Operating income FY2021 −64.49M USD. Operating income FY2022 −179.91M USD. Operating income FY2023 −195.1M USD. Operating income FY2024 −121.32M USD. Operating income FY2025 −93.97M USD. Net income FY2021 −65.58M USD. Net income FY2022 −250.16M USD. Net income FY2023 −113.72M USD. Net income FY2024 −146.57M USD. Net income FY2025 5.7M USD.
Metric (USD)FY2025FY2024FY2023FY2022FY2021
Revenue789K USD144.93M USD
Cost of goods sold4.13M USD3.53M USD19.34M USD
Gross profit−3.34M USD−3.53M USD−19.34M USD144.93M USD
Research and development49.06M USD64.6M USD117.6M USD109.65M USD141.89M USD
Selling, general, and administrative39.16M USD53.18M USD77.5M USD70.26M USD69.26M USD
Operating expenses90.63M USD117.78M USD175.76M USD179.91M USD209.42M USD
Interest income2.23M USD3.97M USD7.3M USD3.06M USD2.87M USD
Interest expense13.18M USD6.02M USD2.91M USD
Depreciation and amortization4.13M USD5.47M USD6.24M USD6.63M USD5.95M USD
Operating income−93.97M USD−121.32M USD−195.1M USD−179.91M USD−64.49M USD
Net income5.7M USD−146.57M USD−113.72M USD−250.16M USD−65.58M USD

Company facts updated Aug 24, 2026.

Earnings

EPS beat rate
64%
7 beats, 4 misses, 0 met estimates
Average EPS surprise
+22.69%
11 comparable reports
Latest EPS result
0.47
Estimate -2.18 · Beat by 121.56%

EPS: actual versus estimate

Recent quarterly results

ActualEstimate
Quarterly EPS actual values compared with estimates1.32-0.5-2.31-4.13Q1 '25MissQ2 '25MissQ3 '25BeatQ4 '25BeatQ1 '26BeatQ2 '26MissQ3 '26BeatQ4 '26Estimate
Q1 2025, reported Mar 13, 2025: actual -1.8, estimate -0.17, surprise -958.82%, Miss. Q2 2025, reported May 7, 2025: actual -3.75, estimate -0.67, surprise -459.70%, Miss. Q3 2025, reported Aug 6, 2025: actual -2.27, estimate -2.72, surprise +16.54%, Beat. Q4 2025, reported Nov 5, 2025: actual 0.94, estimate 0.05, surprise +1780.00%, Beat. Q1 2026, reported Mar 12, 2026: actual -1.78, estimate -2.39, surprise +25.52%, Beat. Q2 2026, reported May 5, 2026: actual -2.08, estimate -1.88, surprise -10.64%, Miss. Q3 2026, reported Aug 5, 2026: actual 0.47, estimate -2.18, surprise +121.56%, Beat. Q4 2026, reported Nov 4, 2026: actual —, estimate -1.01, surprise —, Comparison unavailable.

Revenue: actual versus estimate

Recent quarterly results

ActualEstimate
Quarterly Revenue actual values compared with estimates13.49M9.04M4.6M152.15KQ1 '25EstimateQ2 '25EstimateQ3 '25EstimateQ4 '25MissQ1 '26MissQ2 '26MetQ3 '26BeatQ4 '26Estimate
Q1 2025, reported Mar 13, 2025: actual —, estimate 12.5M USD, surprise —, Comparison unavailable. Q2 2025, reported May 7, 2025: actual —, estimate 10M USD, surprise —, Comparison unavailable. Q3 2025, reported Aug 6, 2025: actual —, estimate 5.88M USD, surprise —, Comparison unavailable. Q4 2025, reported Nov 5, 2025: actual 351K USD, estimate 7.83M USD, surprise -95.52%, Miss. Q1 2026, reported Mar 12, 2026: actual 438K USD, estimate 5.3M USD, surprise -91.74%, Miss. Q2 2026, reported May 5, 2026: actual 358K USD, estimate 358K USD, surprise 0.00%, Met estimate. Q3 2026, reported Aug 5, 2026: actual 736K USD, estimate 179K USD, surprise +311.17%, Beat. Q4 2026, reported Nov 4, 2026: actual —, estimate 6.35M USD, surprise —, Comparison unavailable.

Analyst ratings

Third-party consensus; not a GoAI recommendation.

Analyst price target

Average target

$12.00

163.16% upside
Past 12 months12-month forecastHigh $12.00Average $12.00Low $12.00

Rating distribution

18 ratings
Strong buy00%
Buy1161%
Hold317%
Sell422%
Strong sell00%

Recent analyst actions

5 institutions
JP MorgandowngradeNeutralUnderweight

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