
Spero Therapeutics, Inc.
SPRONASDAQHealthcareBiotechnology
Previous close
$1.22
+$0.01 · +0.83%
SPRO company overview
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GoAI snapshot
AI-powered factor overview
GoAI score
Hold
Wait — insufficient conviction to act
Valuation
91
Deep Value
Momentum
24
Weakening
Sentiment
72
Bullish
Risk resilience
36
High Risk
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Company profile
Company websiteSpero Therapeutics, Inc. is a biopharmaceutical firm in the clinical development stage, primarily focused on discovering, advancing, and commercializing innovative treatments for multi-drug resistant (MDR) bacterial infections and rare diseases within the United States. The company's pipeline includes several key therapeutic candidates: tebipenem pivoxil hydrobromide (HBr), an oral carbapenem-class antibiotic designed to address complicated urinary tract infections (cUTIs), including pyelonephritis, in adult patients. SPR206, an intravenously administered agent specifically developed to combat MDR Gram-negative bacterial infections in hospital environments. SPR720, an oral antibiotic targeting non-tuberculous mycobacterial (NTM) pulmonary disease. Spero Therapeutics has also forged several strategic alliances: A licensing agreement with Meiji Seika Pharma Co., Ltd. supports the ongoing development of tebipenem HBr. A separate licensing deal with Everest Medicines grants rights for the development, manufacturing, and commercialization of SPR206 across Greater China, South Korea, and various Southeast Asian nations. The company collaborates with the Bill & Melinda Gates Medical Research Institute to advance SPR720 for treating lung infections caused by Mycobacterium tuberculosis. Furthermore, a licensing agreement with Vertex Pharmaceuticals Incorporated covers patents associated with SPR720 and its active metabolite, SPR719. Founded in 2013, Spero Therapeutics maintains its corporate headquarters in Cambridge, Massachusetts.
- Industry
- Biotechnology
- Sector
- Healthcare
- Headquarters
- US
- CEO
- Esther Rajavelu
- Listed since
- Nov 2, 2017
- Employees
- 25
Market position
Day range
Current $1.22
52-week range
Current $1.22
- Open
- $1.225
- Previous close
- $1.21
- Volume
- 359.14K
- 0.28× average
- Average volume
- 1.27M
- Average daily volume
- Market cap
- 70.64M USD
- Beta
- 1.48
- Market reference 1
- 50-day average
- $1.7087
- -28.60% below average
- 200-day average
- $2.2789
- -46.46% below average
Financials
Financial snapshot
Latest / TTMValuation & yield
- Enterprise value
- 93.16M USD
- P/E (TTM)
- 8.71×
- P/B (TTM)
- 1.6×
- P/S (TTM)
- 1.64×
- EV / EBITDA
- 10.55×
- Earnings yield
- 6.57%
- Free cash flow yield
- -9.67%
- Dividend yield
- 0.00%
Profitability & efficiency
- Gross margin
- 100.00%
- Operating margin
- 14.02%
- Net margin
- 17.18%
- Return on equity
- 14.52%
- Return on assets
- 12.44%
- Return on invested capital
- -0.04%
Financial health
- Debt / equity
- 0.05×
- Current ratio
- 7.59×
Financial statements
Margin trends
Profitability as a percentage of reported revenue.
Income trends
Revenue
Operating income
Net income
| Metric (USD) | FY2025 | FY2024 | FY2023 | FY2022 | FY2021 |
|---|---|---|---|---|---|
| Revenue | 59.62M USD | 47.98M USD | 103.78M USD | 48.58M USD | 3.07M USD |
| Cost of goods sold | — | 96.76M USD | 51.44M USD | — | — |
| Gross profit | 59.62M USD | −48.78M USD | 52.34M USD | 48.58M USD | 3.07M USD |
| Research and development | 38.47M USD | 96.76M USD | 51.44M USD | 47.59M USD | 64.53M USD |
| Selling, general, and administrative | 21.18M USD | 23.7M USD | 25.55M USD | 36.48M USD | 41.7M USD |
| Operating expenses | 59.64M USD | 24.58M USD | 30.86M USD | 90.78M USD | 91.04M USD |
| Interest income | 2.51M USD | 4.74M USD | 3.94M USD | 1.11M USD | 346K USD |
| Interest expense | — | — | — | 2.61M USD | 1.94M USD |
| Depreciation and amortization | — | 2K USD | 367K USD | 869K USD | 646K USD |
| Operating income | −24K USD | −73.36M USD | 21.48M USD | −42.2M USD | −87.97M USD |
| Net income | 8.57M USD | −68.57M USD | 22.81M USD | −46.42M USD | −89.76M USD |
Company facts updated Aug 24, 2026.
Earnings
- EPS beat rate
- 73%
- 8 beats, 3 misses, 0 met estimates
- Average EPS surprise
- +126.28%
- 11 comparable reports
- Latest EPS result
- -0.16
- Estimate -0.17 · Beat by 5.88%
EPS: actual versus estimate
Recent quarterly results
Revenue: actual versus estimate
Recent quarterly results
Corporate actions
Annual dividends per share
Cash distributions grouped by calendar year; partial years are marked.
$0.06
2014 complete year+50.0% since 2010
$0.04
2,010
$0.04
2,011
$0.04
2,012
$0.06
2,013
$0.06
2,014
Corporate action history
| Action | Ex-dividend date | Details | Record date | Payment date |
|---|---|---|---|---|
Dividend | Sep 16, 2015 | $0.015Quarterly | Sep 18, 2015 | Oct 7, 2015 |
Dividend | Jun 17, 2015 | $0.015Quarterly | Jun 19, 2015 | Jul 7, 2015 |
Dividend | Mar 18, 2015 | $0.015Quarterly | Mar 20, 2015 | Apr 7, 2015 |
Dividend | Dec 17, 2014 | $0.015Quarterly | Dec 19, 2014 | Jan 6, 2015 |
Dividend | Sep 17, 2014 | $0.015Quarterly | Sep 19, 2014 | Oct 7, 2014 |
Dividend | Jun 18, 2014 | $0.015Quarterly | Jun 20, 2014 | Jul 7, 2014 |
Ex-dividend Sep 16, 2015
$0.015
Quarterly
Record Sep 18, 2015 · Payment Oct 7, 2015
Ex-dividend Jun 17, 2015
$0.015
Quarterly
Record Jun 19, 2015 · Payment Jul 7, 2015
Ex-dividend Mar 18, 2015
$0.015
Quarterly
Record Mar 20, 2015 · Payment Apr 7, 2015
Ex-dividend Dec 17, 2014
$0.015
Quarterly
Record Dec 19, 2014 · Payment Jan 6, 2015
Ex-dividend Sep 17, 2014
$0.015
Quarterly
Record Sep 19, 2014 · Payment Oct 7, 2014
Ex-dividend Jun 18, 2014
$0.015
Quarterly
Record Jun 20, 2014 · Payment Jul 7, 2014
SPRO peers
ETFs holding SPRO
Funds reporting this stock among their holdings, ordered by reported position size.
Vanguard Morningstar Total Stock Market ETFVTI1.63M0.00%2.3T USD0.03%$378.24+0.44%
Vanguard Extended Market ETFVXF694.11K0.00%93.7B USD0.05%$245.53+0.82%
iShares Micro-Cap ETFIWC185.36K0.01%1.53B USD0.60%$198.39+1.10%
Invesco NASDAQ Future Gen 200 ETFQQQS47.81K0.21%22.98M USD0.20%$45.0826+1.10%
Invesco RAFI US 1500 Small-Mid ETFPRFZ32.55K0.00%2.87B USD0.34%$55.89+0.87%
Dimensional - US Small Cap ETFDFAS31.18K0.00%15.92B USD0.26%$83.02+0.73%
U.S. Micro Cap Portfolio ETFDFMC22.04K0.00%8.06B USD0.43%$60.95+0.73%
Dimensional - US Targeted Value ETFDFAT19.43K0.00%14.66B USD0.28%$71.67+0.67%
Vanguard Morningstar Total Stock Market ETFVTI- Market value
- 1.63M
- Weight
- 0.00%
- AUM
- 2.3T USD
- Expense ratio
- 0.03%
- Price / 1D
- $378.24+0.44%
Vanguard Extended Market ETFVXF- Market value
- 694.11K
- Weight
- 0.00%
- AUM
- 93.7B USD
- Expense ratio
- 0.05%
- Price / 1D
- $245.53+0.82%
iShares Micro-Cap ETFIWC- Market value
- 185.36K
- Weight
- 0.01%
- AUM
- 1.53B USD
- Expense ratio
- 0.60%
- Price / 1D
- $198.39+1.10%
Invesco NASDAQ Future Gen 200 ETFQQQS- Market value
- 47.81K
- Weight
- 0.21%
- AUM
- 22.98M USD
- Expense ratio
- 0.20%
- Price / 1D
- $45.0826+1.10%
Invesco RAFI US 1500 Small-Mid ETFPRFZ- Market value
- 32.55K
- Weight
- 0.00%
- AUM
- 2.87B USD
- Expense ratio
- 0.34%
- Price / 1D
- $55.89+0.87%
Dimensional - US Small Cap ETFDFAS- Market value
- 31.18K
- Weight
- 0.00%
- AUM
- 15.92B USD
- Expense ratio
- 0.26%
- Price / 1D
- $83.02+0.73%
U.S. Micro Cap Portfolio ETFDFMC- Market value
- 22.04K
- Weight
- 0.00%
- AUM
- 8.06B USD
- Expense ratio
- 0.43%
- Price / 1D
- $60.95+0.73%
Dimensional - US Targeted Value ETFDFAT- Market value
- 19.43K
- Weight
- 0.00%
- AUM
- 14.66B USD
- Expense ratio
- 0.28%
- Price / 1D
- $71.67+0.67%
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