Spero Therapeutics, Inc. logo

Spero Therapeutics, Inc.

SPRO

NASDAQHealthcareBiotechnology

Previous close

$1.22

+$0.01 · +0.83%

Aug 21, 4:00 PM ET

SPRO company overview

Regular session · ET · Market data may be delayed.

GoAI snapshot

AI-powered factor overview

Jul 10, 2026

GoAI score

Hold

Wait — insufficient conviction to act

Valuation

91

Deep Value

Momentum

24

Weakening

Sentiment

72

Bullish

Risk resilience

36

High Risk

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Company profile

Company website

Spero Therapeutics, Inc. is a biopharmaceutical firm in the clinical development stage, primarily focused on discovering, advancing, and commercializing innovative treatments for multi-drug resistant (MDR) bacterial infections and rare diseases within the United States. The company's pipeline includes several key therapeutic candidates: tebipenem pivoxil hydrobromide (HBr), an oral carbapenem-class antibiotic designed to address complicated urinary tract infections (cUTIs), including pyelonephritis, in adult patients. SPR206, an intravenously administered agent specifically developed to combat MDR Gram-negative bacterial infections in hospital environments. SPR720, an oral antibiotic targeting non-tuberculous mycobacterial (NTM) pulmonary disease. Spero Therapeutics has also forged several strategic alliances: A licensing agreement with Meiji Seika Pharma Co., Ltd. supports the ongoing development of tebipenem HBr. A separate licensing deal with Everest Medicines grants rights for the development, manufacturing, and commercialization of SPR206 across Greater China, South Korea, and various Southeast Asian nations. The company collaborates with the Bill & Melinda Gates Medical Research Institute to advance SPR720 for treating lung infections caused by Mycobacterium tuberculosis. Furthermore, a licensing agreement with Vertex Pharmaceuticals Incorporated covers patents associated with SPR720 and its active metabolite, SPR719. Founded in 2013, Spero Therapeutics maintains its corporate headquarters in Cambridge, Massachusetts.

Industry
Biotechnology
Sector
Healthcare
Headquarters
US
CEO
Esther Rajavelu
Listed since
Nov 2, 2017
Employees
25

Market position

Day range

Current $1.22

52-week range

Current $1.22

Open
$1.225
Previous close
$1.21
Volume
359.14K
0.28× average
Average volume
1.27M
Average daily volume
Market cap
70.64M USD
Beta
1.48
Market reference 1
50-day average
$1.7087
-28.60% below average
200-day average
$2.2789
-46.46% below average

Financials

Financial snapshot

Latest / TTM

Valuation & yield

Enterprise value
93.16M USD
P/E (TTM)
8.71×
P/B (TTM)
1.6×
P/S (TTM)
1.64×
EV / EBITDA
10.55×
Earnings yield
6.57%
Free cash flow yield
-9.67%
Dividend yield
0.00%

Profitability & efficiency

Gross margin
100.00%
Operating margin
14.02%
Net margin
17.18%
Return on equity
14.52%
Return on assets
12.44%
Return on invested capital
-0.04%

Financial health

Debt / equity
0.05×
Current ratio
7.59×

Financial statements

Margin trends

Profitability as a percentage of reported revenue.

Gross marginOperating marginNet margin
Gross, operating, and net margin trends402%-807%-2017%-3226%Gross margin, FY2021: 100.00%Gross margin, FY2022: 100.00%Gross margin, FY2023: 50.43%Gross margin, FY2024: -101.67%Gross margin, FY2025: 100.00%Operating margin, FY2021: -2865.50%Operating margin, FY2022: -86.86%Operating margin, FY2023: 20.70%Operating margin, FY2024: -152.91%Operating margin, FY2025: -0.04%Net margin, FY2021: -2923.65%Net margin, FY2022: -95.55%Net margin, FY2023: 21.98%Net margin, FY2024: -142.91%Net margin, FY2025: 14.38%FY2021FY2022FY2023FY2024FY2025
Gross margin FY2021 100.00%. Gross margin FY2022 100.00%. Gross margin FY2023 50.43%. Gross margin FY2024 -101.67%. Gross margin FY2025 100.00%. Operating margin FY2021 -2865.50%. Operating margin FY2022 -86.86%. Operating margin FY2023 20.70%. Operating margin FY2024 -152.91%. Operating margin FY2025 -0.04%. Net margin FY2021 -2923.65%. Net margin FY2022 -95.55%. Net margin FY2023 21.98%. Net margin FY2024 -142.91%. Net margin FY2025 14.38%.

Income trends

Revenue

59.62M USD+24.27%

Operating income

−24K USD+99.97%

Net income

8.57M USD+77.14M USD
Income trends across reported periods123.13M USD45.72M USD−31.69M USD−109.11M USDRevenue, FY2021: 3.07M USDRevenue, FY2022: 48.58M USDRevenue, FY2023: 103.78M USDRevenue, FY2024: 47.98M USDRevenue, FY2025: 59.62M USDOperating income, FY2021: −87.97M USDOperating income, FY2022: −42.2M USDOperating income, FY2023: 21.48M USDOperating income, FY2024: −73.36M USDOperating income, FY2025: −24K USDNet income, FY2021: −89.76M USDNet income, FY2022: −46.42M USDNet income, FY2023: 22.81M USDNet income, FY2024: −68.57M USDNet income, FY2025: 8.57M USDFY2021FY2022FY2023FY2024FY2025
Revenue FY2021 3.07M USD. Revenue FY2022 48.58M USD. Revenue FY2023 103.78M USD. Revenue FY2024 47.98M USD. Revenue FY2025 59.62M USD. Operating income FY2021 −87.97M USD. Operating income FY2022 −42.2M USD. Operating income FY2023 21.48M USD. Operating income FY2024 −73.36M USD. Operating income FY2025 −24K USD. Net income FY2021 −89.76M USD. Net income FY2022 −46.42M USD. Net income FY2023 22.81M USD. Net income FY2024 −68.57M USD. Net income FY2025 8.57M USD.
Metric (USD)FY2025FY2024FY2023FY2022FY2021
Revenue59.62M USD47.98M USD103.78M USD48.58M USD3.07M USD
Cost of goods sold96.76M USD51.44M USD
Gross profit59.62M USD−48.78M USD52.34M USD48.58M USD3.07M USD
Research and development38.47M USD96.76M USD51.44M USD47.59M USD64.53M USD
Selling, general, and administrative21.18M USD23.7M USD25.55M USD36.48M USD41.7M USD
Operating expenses59.64M USD24.58M USD30.86M USD90.78M USD91.04M USD
Interest income2.51M USD4.74M USD3.94M USD1.11M USD346K USD
Interest expense2.61M USD1.94M USD
Depreciation and amortization2K USD367K USD869K USD646K USD
Operating income−24K USD−73.36M USD21.48M USD−42.2M USD−87.97M USD
Net income8.57M USD−68.57M USD22.81M USD−46.42M USD−89.76M USD

Company facts updated Aug 24, 2026.

Earnings

EPS beat rate
73%
8 beats, 3 misses, 0 met estimates
Average EPS surprise
+126.28%
11 comparable reports
Latest EPS result
-0.16
Estimate -0.17 · Beat by 5.88%

EPS: actual versus estimate

Recent quarterly results

ActualEstimate
Quarterly EPS actual values compared with estimates0.620.2-0.22-0.64Q1 '25MissQ2 '25BeatQ3 '25BeatQ4 '25BeatQ1 '26BeatQ2 '26BeatQ3 '26BeatQ4 '26Estimate
Q1 2025, reported Mar 27, 2025: actual -0.38, estimate -0.35, surprise -8.57%, Miss. Q2 2025, reported May 13, 2025: actual -0.25, estimate -0.55, surprise +54.55%, Beat. Q3 2025, reported Aug 12, 2025: actual -0.03, estimate -0.38, surprise +92.11%, Beat. Q4 2025, reported Nov 13, 2025: actual -0.13, estimate -0.25, surprise +48.00%, Beat. Q1 2026, reported Mar 26, 2026: actual 0.53, estimate -0.2, surprise +365.00%, Beat. Q2 2026, reported May 13, 2026: actual -0.13, estimate -0.18, surprise +27.78%, Beat. Q3 2026, reported Aug 12, 2026: actual -0.16, estimate -0.17, surprise +5.88%, Beat. Q4 2026, reported Nov 12, 2026: actual —, estimate -0.16, surprise —, Comparison unavailable.

Revenue: actual versus estimate

Recent quarterly results

ActualEstimate
Quarterly Revenue actual values compared with estimates44.58M29.79M15.01M219.3KQ3 '24BeatQ4 '24BeatQ1 '25BeatQ2 '25MissQ3 '25BeatQ4 '25MissQ1 '26BeatQ2 '26Met
Q3 2024, reported Aug 5, 2024: actual 6.02M USD, estimate 4.9M USD, surprise +22.80%, Beat. Q4 2024, reported Nov 14, 2024: actual 13.47M USD, estimate 4.13M USD, surprise +225.86%, Beat. Q1 2025, reported Mar 27, 2025: actual 9.36M USD, estimate 6.2M USD, surprise +50.90%, Beat. Q2 2025, reported May 13, 2025: actual 5.87M USD, estimate 11M USD, surprise -46.60%, Miss. Q3 2025, reported Aug 12, 2025: actual 11.8M USD, estimate 11M USD, surprise +7.29%, Beat. Q4 2025, reported Nov 13, 2025: actual 3.05M USD, estimate 12M USD, surprise -74.60%, Miss. Q1 2026, reported Mar 26, 2026: actual 41.3M USD, estimate 26M USD, surprise +58.83%, Beat. Q2 2026, reported May 13, 2026: actual 258K USD, estimate 258K USD, surprise 0.00%, Met estimate.

Corporate actions

Annual dividends per share

Cash distributions grouped by calendar year; partial years are marked.

$0.06

2014 complete year+50.0% since 2010

Corporate action history

Dividend

Ex-dividend Sep 16, 2015

$0.015

Quarterly

Record Sep 18, 2015 · Payment Oct 7, 2015

Dividend

Ex-dividend Jun 17, 2015

$0.015

Quarterly

Record Jun 19, 2015 · Payment Jul 7, 2015

Dividend

Ex-dividend Mar 18, 2015

$0.015

Quarterly

Record Mar 20, 2015 · Payment Apr 7, 2015

Dividend

Ex-dividend Dec 17, 2014

$0.015

Quarterly

Record Dec 19, 2014 · Payment Jan 6, 2015

Dividend

Ex-dividend Sep 17, 2014

$0.015

Quarterly

Record Sep 19, 2014 · Payment Oct 7, 2014

Dividend

Ex-dividend Jun 18, 2014

$0.015

Quarterly

Record Jun 20, 2014 · Payment Jul 7, 2014

SPRO peers

ETFs holding SPRO

Funds reporting this stock among their holdings, ordered by reported position size.

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