AnGes, Inc. logo

AnGes, Inc.

4563.T

JPXHealthcareBiotechnology

Latest quote

¥40.00

+¥1.00 · +2.56%

Aug 24, 1:18 PM JST

4563.T company overview

Regular session · JST · Market data may be delayed.

Company profile

Company website

AnGes, Inc., a biopharmaceutical firm headquartered in Ibaraki, Japan, and established in 1999, focuses on pioneering the research and development of gene-based medical solutions. Its primary therapeutic asset is Hepatocyte Growth Factor (HGF) Plasmid, an innovative gene therapy designed to address critical limb ischemia, a severe circulatory condition impacting the legs. The company's diverse pipeline also includes NF-kB Decoy Oligonucleotide, a nucleic acid medicine formulated to suppress inflammation for various ailments, including low back pain. Furthermore, AnGes is actively developing treatments for atopic dermatitis and disc degeneration, as well as specialized medical devices aimed at preventing vascular restenosis. Their development endeavors also extend to therapeutic vaccines for cervical intraepithelial neoplasia, a precursor to cervical cancer, and, through a research partnership with Osaka University, DNA vaccines targeting hypertension. AnGes fosters strategic alliances to expand its global reach and product commercialization. These collaborations include BioMarin Pharmaceutical Inc. for the Japanese market distribution of Naglazyme, a drug for mucopolysaccharidosis VI; and Mitsubishi Tanabe Pharma Corporation, which handles the marketing of HGF Plasmid for peripheral arterial disease in both the United States and Japan. Other key partners are SHIONOGI & CO., LTD. for the commercialization of topical NF-kB decoy oligonucleotide drugs for dermatological conditions, and Vical, Inc. for the development and marketing of Allovectin, a cancer treatment. Additionally, AnGes has joined forces with Osaka University to develop a coronavirus vaccine, and with Brickell Biotech, Inc. for an investigational plasmid DNA vaccine intended to prevent coronavirus across the U.S., South America, and other territories. The company, previously known as AnGes MG, Inc., officially rebranded to AnGes, Inc. in July 2017.

Industry
Biotechnology
Sector
Healthcare
Headquarters
JP
CEO
Ei Yamada
Listed since
Sep 25, 2002
Employees
56

Market position

Day range

Current ¥40.00

52-week range

Current ¥40.00

Open
¥39.00
Previous close
¥39.00
Volume
1.31M
0.85× average
Average volume
1.54M
Average daily volume
Market cap
15.83B JPY
Beta
0.64
Market reference 1
50-day average
¥47.42
-15.65% below average
200-day average
¥56.24
-28.88% below average

Financials

Financial snapshot

Latest / TTM

Valuation & yield

Enterprise value
19.82B JPY
P/E (TTM)
-4.2×
P/B (TTM)
77.28×
P/S (TTM)
16.45×
EV / EBITDA
-3.89×
Earnings yield
-23.67%
Free cash flow yield
-26.63%
Dividend yield
0.00%

Profitability & efficiency

Gross margin
41.38%
Operating margin
-621.79%
Net margin
-402.50%
Return on equity
-166.55%
Return on assets
-94.77%
Return on invested capital
-156.49%

Financial health

Debt / equity
3.52×
Current ratio
1.96×

Financial statements

Margin trends

Profitability as a percentage of reported revenue.

Gross marginOperating marginNet margin
Gross, operating, and net margin trends2479%-7284%-17047%-26810%Gross margin, FY2021: 11.58%Gross margin, FY2022: -40.01%Gross margin, FY2023: 12.71%Gross margin, FY2024: 38.41%Gross margin, FY2025: 36.65%Operating margin, FY2021: -24369.16%Operating margin, FY2022: -24331.28%Operating margin, FY2023: -7822.66%Operating margin, FY2024: -1416.71%Operating margin, FY2025: -588.64%Net margin, FY2021: -21319.14%Net margin, FY2022: -21942.37%Net margin, FY2023: -4861.66%Net margin, FY2024: -4374.65%Net margin, FY2025: -586.11%FY2021FY2022FY2023FY2024FY2025
Gross margin FY2021 11.58%. Gross margin FY2022 -40.01%. Gross margin FY2023 12.71%. Gross margin FY2024 38.41%. Gross margin FY2025 36.65%. Operating margin FY2021 -24369.16%. Operating margin FY2022 -24331.28%. Operating margin FY2023 -7822.66%. Operating margin FY2024 -1416.71%. Operating margin FY2025 -588.64%. Net margin FY2021 -21319.14%. Net margin FY2022 -21942.37%. Net margin FY2023 -4861.66%. Net margin FY2024 -4374.65%. Net margin FY2025 -586.11%.

Income trends

Revenue

874.12M JPY+35.94%

Operating income

−5.15B JPY+43.52%

Net income

−5.12B JPY+81.79%
Income trends across reported periods3.77B JPY−7.83B JPY−19.43B JPY−31.03B JPYRevenue, FY2021: 64.15M JPYRevenue, FY2022: 67.06M JPYRevenue, FY2023: 152.99M JPYRevenue, FY2024: 643M JPYRevenue, FY2025: 874.12M JPYOperating income, FY2021: −15.63B JPYOperating income, FY2022: −16.32B JPYOperating income, FY2023: −11.97B JPYOperating income, FY2024: −9.11B JPYOperating income, FY2025: −5.15B JPYNet income, FY2021: −13.68B JPYNet income, FY2022: −14.71B JPYNet income, FY2023: −7.44B JPYNet income, FY2024: −28.13B JPYNet income, FY2025: −5.12B JPYFY2021FY2022FY2023FY2024FY2025
Revenue FY2021 64.15M JPY. Revenue FY2022 67.06M JPY. Revenue FY2023 152.99M JPY. Revenue FY2024 643M JPY. Revenue FY2025 874.12M JPY. Operating income FY2021 −15.63B JPY. Operating income FY2022 −16.32B JPY. Operating income FY2023 −11.97B JPY. Operating income FY2024 −9.11B JPY. Operating income FY2025 −5.15B JPY. Net income FY2021 −13.68B JPY. Net income FY2022 −14.71B JPY. Net income FY2023 −7.44B JPY. Net income FY2024 −28.13B JPY. Net income FY2025 −5.12B JPY.
Metric (JPY)FY2025FY2024FY2023FY2022FY2021
Revenue874.12M JPY643M JPY152.99M JPY67.06M JPY64.15M JPY
Cost of goods sold553.74M JPY396M JPY134M JPY93.89M JPY56.72M JPY
Gross profit320.38M JPY247M JPY19.45M JPY−26.83M JPY7.43M JPY
Research and development3.55B JPY3.78B JPY6.17B JPY10.99B JPY10.78B JPY
Selling, general, and administrative1.91B JPY5.57B JPY2.51B JPY2.1B JPY4.86B JPY
Operating expenses5.47B JPY9.36B JPY11.99B JPY16.29B JPY15.64B JPY
Interest income14.86M JPY4.45M JPY8.41M JPY1.83M JPY566K JPY
Interest expense20.22M JPY24.95M JPY96.14M JPY
Depreciation and amortization53.84M JPY3.37B JPY3.11B JPY2.9B JPY2.43B JPY
Operating income−5.15B JPY−9.11B JPY−11.97B JPY−16.32B JPY−15.63B JPY
Net income−5.12B JPY−28.13B JPY−7.44B JPY−14.71B JPY−13.68B JPY

Company facts updated Aug 24, 2026.

Earnings

Latest EPS result
-4.11

EPS: actual versus estimate

Recent quarterly results

ActualEstimate
Estimates unavailable
Quarterly EPS actual values compared with estimates-0.69-27.73-54.76-81.8Q4 '24Q1 '25Q2 '25Q3 '25Q4 '25Q1 '26Q2 '26Q3 '26
Q4 2024, reported Nov 8, 2024: actual -15.06, estimate —, surprise —, Comparison unavailable. Q1 2025, reported Feb 14, 2025: actual -75.8, estimate —, surprise —, Comparison unavailable. Q2 2025, reported May 9, 2025: actual -3.98, estimate —, surprise —, Comparison unavailable. Q3 2025, reported Aug 8, 2025: actual -8.68, estimate —, surprise —, Comparison unavailable. Q4 2025, reported Nov 7, 2025: actual -1.87, estimate —, surprise —, Comparison unavailable. Q1 2026, reported Feb 10, 2026: actual -0.81, estimate —, surprise —, Comparison unavailable. Q2 2026, reported May 8, 2026: actual -2.74, estimate —, surprise —, Comparison unavailable. Q3 2026, reported Aug 14, 2026: actual -4.11, estimate —, surprise —, Comparison unavailable.

Revenue: actual versus estimate

Recent quarterly results

ActualEstimate
Estimates unavailable
Quarterly Revenue actual values compared with estimates313M245.33M177.67M110MQ4 '24Q1 '25Q2 '25Q3 '25Q4 '25Q1 '26Q2 '26Q3 '26
Q4 2024, reported Nov 8, 2024: actual 124M JPY, estimate —, surprise —, Comparison unavailable. Q1 2025, reported Feb 14, 2025: actual 172M JPY, estimate —, surprise —, Comparison unavailable. Q2 2025, reported May 9, 2025: actual 169.24M JPY, estimate —, surprise —, Comparison unavailable. Q3 2025, reported Aug 8, 2025: actual 245.74M JPY, estimate —, surprise —, Comparison unavailable. Q4 2025, reported Nov 7, 2025: actual 231.16M JPY, estimate —, surprise —, Comparison unavailable. Q1 2026, reported Feb 10, 2026: actual 228M JPY, estimate —, surprise —, Comparison unavailable. Q2 2026, reported May 8, 2026: actual 203M JPY, estimate —, surprise —, Comparison unavailable. Q3 2026, reported Aug 14, 2026: actual 299M JPY, estimate —, surprise —, Comparison unavailable.

Corporate actions

Corporate action history

Stock split

Effective Jul 29, 2014

46:39

Stock split

Effective Dec 26, 2013

100:1

Stock split

Effective Jun 26, 2013

2:1

4563.T peers

ETFs holding 4563.T

Funds reporting this stock among their holdings, ordered by reported position size.

Continue in GoAI

Research 4563.T

research.disclaimer