
AnGes, Inc.
4563.TJPXHealthcareBiotechnology
Latest quote
¥40.00
+¥1.00 · +2.56%
4563.T company overview
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Company profile
Company websiteAnGes, Inc., a biopharmaceutical firm headquartered in Ibaraki, Japan, and established in 1999, focuses on pioneering the research and development of gene-based medical solutions. Its primary therapeutic asset is Hepatocyte Growth Factor (HGF) Plasmid, an innovative gene therapy designed to address critical limb ischemia, a severe circulatory condition impacting the legs. The company's diverse pipeline also includes NF-kB Decoy Oligonucleotide, a nucleic acid medicine formulated to suppress inflammation for various ailments, including low back pain. Furthermore, AnGes is actively developing treatments for atopic dermatitis and disc degeneration, as well as specialized medical devices aimed at preventing vascular restenosis. Their development endeavors also extend to therapeutic vaccines for cervical intraepithelial neoplasia, a precursor to cervical cancer, and, through a research partnership with Osaka University, DNA vaccines targeting hypertension. AnGes fosters strategic alliances to expand its global reach and product commercialization. These collaborations include BioMarin Pharmaceutical Inc. for the Japanese market distribution of Naglazyme, a drug for mucopolysaccharidosis VI; and Mitsubishi Tanabe Pharma Corporation, which handles the marketing of HGF Plasmid for peripheral arterial disease in both the United States and Japan. Other key partners are SHIONOGI & CO., LTD. for the commercialization of topical NF-kB decoy oligonucleotide drugs for dermatological conditions, and Vical, Inc. for the development and marketing of Allovectin, a cancer treatment. Additionally, AnGes has joined forces with Osaka University to develop a coronavirus vaccine, and with Brickell Biotech, Inc. for an investigational plasmid DNA vaccine intended to prevent coronavirus across the U.S., South America, and other territories. The company, previously known as AnGes MG, Inc., officially rebranded to AnGes, Inc. in July 2017.
- Industry
- Biotechnology
- Sector
- Healthcare
- Headquarters
- JP
- CEO
- Ei Yamada
- Listed since
- Sep 25, 2002
- Employees
- 56
Market position
Day range
Current ¥40.00
52-week range
Current ¥40.00
- Open
- ¥39.00
- Previous close
- ¥39.00
- Volume
- 1.31M
- 0.85× average
- Average volume
- 1.54M
- Average daily volume
- Market cap
- 15.83B JPY
- Beta
- 0.64
- Market reference 1
- 50-day average
- ¥47.42
- -15.65% below average
- 200-day average
- ¥56.24
- -28.88% below average
Financials
Financial snapshot
Latest / TTMValuation & yield
- Enterprise value
- 19.82B JPY
- P/E (TTM)
- -4.2×
- P/B (TTM)
- 77.28×
- P/S (TTM)
- 16.45×
- EV / EBITDA
- -3.89×
- Earnings yield
- -23.67%
- Free cash flow yield
- -26.63%
- Dividend yield
- 0.00%
Profitability & efficiency
- Gross margin
- 41.38%
- Operating margin
- -621.79%
- Net margin
- -402.50%
- Return on equity
- -166.55%
- Return on assets
- -94.77%
- Return on invested capital
- -156.49%
Financial health
- Debt / equity
- 3.52×
- Current ratio
- 1.96×
Financial statements
Margin trends
Profitability as a percentage of reported revenue.
Income trends
Revenue
Operating income
Net income
| Metric (JPY) | FY2025 | FY2024 | FY2023 | FY2022 | FY2021 |
|---|---|---|---|---|---|
| Revenue | 874.12M JPY | 643M JPY | 152.99M JPY | 67.06M JPY | 64.15M JPY |
| Cost of goods sold | 553.74M JPY | 396M JPY | 134M JPY | 93.89M JPY | 56.72M JPY |
| Gross profit | 320.38M JPY | 247M JPY | 19.45M JPY | −26.83M JPY | 7.43M JPY |
| Research and development | 3.55B JPY | 3.78B JPY | 6.17B JPY | 10.99B JPY | 10.78B JPY |
| Selling, general, and administrative | 1.91B JPY | 5.57B JPY | 2.51B JPY | 2.1B JPY | 4.86B JPY |
| Operating expenses | 5.47B JPY | 9.36B JPY | 11.99B JPY | 16.29B JPY | 15.64B JPY |
| Interest income | 14.86M JPY | 4.45M JPY | 8.41M JPY | 1.83M JPY | 566K JPY |
| Interest expense | — | — | 20.22M JPY | 24.95M JPY | 96.14M JPY |
| Depreciation and amortization | 53.84M JPY | 3.37B JPY | 3.11B JPY | 2.9B JPY | 2.43B JPY |
| Operating income | −5.15B JPY | −9.11B JPY | −11.97B JPY | −16.32B JPY | −15.63B JPY |
| Net income | −5.12B JPY | −28.13B JPY | −7.44B JPY | −14.71B JPY | −13.68B JPY |
Company facts updated Aug 24, 2026.
Earnings
- Latest EPS result
- -4.11
EPS: actual versus estimate
Recent quarterly results
Revenue: actual versus estimate
Recent quarterly results
Corporate actions
Corporate action history
| Action | Effective date | Details | Record date | Payment date |
|---|---|---|---|---|
Stock split | Jul 29, 2014 | 46:39 | — | — |
Stock split | Dec 26, 2013 | 100:1 | — | — |
Stock split | Jun 26, 2013 | 2:1 | — | — |
Effective Jul 29, 2014
46:39
Effective Dec 26, 2013
100:1
Effective Jun 26, 2013
2:1
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